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Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family

Heterotrimeric G proteins are categorized into four main families based on their function and sequence, Gs, Gi/o, Gq/11, and G12/13. One receptor can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. However, the precise mechanism und...

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Detalles Bibliográficos
Autores principales:	Kim, Hee Ryung, Xu, Jun, Maeda, Shoji, Duc, Nguyen Minh, Ahn, Donghoon, Du, Yang, Chung, Ka Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308389/ https://www.ncbi.nlm.nih.gov/pubmed/32572026 http://dx.doi.org/10.1038/s41467-020-16975-2

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