Cargando…

DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner

Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage Response (DDR), which includes phosphorylation of histone H2Ax, forming γH2Ax. This histone modification spreads beyond the DSB into neighboring chromatin, generating a DDR platform that protects against end disass...

Descripción completa

Detalles Bibliográficos
Autores principales:	Collins, Patrick L., Purman, Caitlin, Porter, Sofia I., Nganga, Vincent, Saini, Ankita, Hayer, Katharina E., Gurewitz, Greer L., Sleckman, Barry P., Bednarski, Jeffrey J., Bassing, Craig H., Oltz, Eugene M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308414/ https://www.ncbi.nlm.nih.gov/pubmed/32572033 http://dx.doi.org/10.1038/s41467-020-16926-x

Ejemplares similares

Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination
por: Yin, Bu, et al.
Publicado: (2009)

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
por: Helmink, Beth A., et al.
Publicado: (2009)

Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks
por: Rybak, Paulina, et al.
Publicado: (2016)

H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues
por: Firsanov, Denis V., et al.
Publicado: (2011)

H2AX Prevents CtIP-Mediated DNA End Resection and Aberrant Repair in G1-Phase Lymphocytes
por: Helmink, Beth A., et al.
Publicado: (2010)

RAG-mediated DNA double-strand breaks activate a cell type–specific checkpoint to inhibit pre–B cell receptor signals
por: Bednarski, Jeffrey J., et al.
Publicado: (2016)

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
por: Jakob, Burkhard, et al.
Publicado: (2011)

RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferation
por: Bednarski, Jeffrey J., et al.
Publicado: (2012)

Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus
por: Namas, Rajaie, et al.
Publicado: (2016)

H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype
por: Vasireddy, R S, et al.
Publicado: (2010)

γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
por: Kinner, Andrea, et al.
Publicado: (2008)

The regulation of DNA end resection by chromatin response to DNA double strand breaks
por: Chen, Bo-Ruei, et al.
Publicado: (2022)

Phosphorylation: The Molecular Switch of Double-Strand Break Repair
por: Summers, K. C., et al.
Publicado: (2011)

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks
por: Caron, Pierre, et al.
Publicado: (2012)

DNA double strand breaks activate a multi-functional genetic program in developing lymphocytes
por: Bredemeyer, Andrea L., et al.
Publicado: (2008)

An Analytical Method for Quantifying the Yields of DNA Double-Strand Breaks Coupled with Strand Breaks by γ-H2AX Focus Formation Assay Based on Track-Structure Simulation
por: Yachi, Yoshie, et al.
Publicado: (2023)

Recent developments in the use of γ -H2AX as a quantitative DNA double-strand break biomarker
por: Redon, Christophe E., et al.
Publicado: (2011)

Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses
por: Jacobs, Keith M., et al.
Publicado: (2016)

Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma
por: Hu, Jin-lin, et al.
Publicado: (2015)

Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX
por: Okabe, Asako, et al.
Publicado: (2019)

Endogenous DNA breaks: γH2AX and the role of telomeres
por: Olive, Peggy L.
Publicado: (2009)

Calibration of the γ-H2AX DNA Double Strand Break Focus Assay for Internal Radiation Exposure of Blood Lymphocytes
por: Eberlein, Uta, et al.
Publicado: (2015)

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
por: Turinetto, Valentina, et al.
Publicado: (2015)

Restrictions Limiting the Generation of DNA Double Strand Breaks during Chromosomal V(D)J Recombination
por: Tillman, Robert E., et al.
Publicado: (2002)

Phosphorylation of Histone H2B at DNA Double-Strand Breaks
por: Fernandez-Capetillo, Oscar, et al.
Publicado: (2004)

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks
por: Mah, Li-Jeen, et al.
Publicado: (2011)

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing Radiation
por: Valente, Davide, et al.
Publicado: (2022)

Detection of DNA Double Strand Breaks by γH2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues
por: Müller, Brigitte, et al.
Publicado: (2018)

DNA Double Strand Break Repair in Mitosis Is Suppressed by Phosphorylation of XRCC4
por: Lees-Miller, Susan P.
Publicado: (2014)

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
por: Gelot, Camille, et al.
Publicado: (2023)

The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair
por: Fenton, Amanda L., et al.
Publicado: (2013)

RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner
por: Kuo, Ching-Ying, et al.
Publicado: (2016)

APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
por: Imamura, Rikiya, et al.
Publicado: (2023)

γH2AX, a DNA Double-Strand Break Marker, Correlates with PD-L1 Expression in Smoking-Related Lung Adenocarcinoma
por: Sakurai, Eiko, et al.
Publicado: (2022)

The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair
por: Qiu, Lingyu, et al.
Publicado: (2023)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

NBN Phosphorylation regulates the accumulation of MRN and ATM at sites of DNA Double-Strand Breaks
por: Wen, Jie, et al.
Publicado: (2012)

The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age
por: Merighi, Adalberto, et al.
Publicado: (2021)

Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced γH2A.X Foci
por: Markunas, Christina A., et al.
Publicado: (2008)

Evaluation of machine learning models for automatic detection of DNA double strand breaks after irradiation using a γH2AX foci assay
por: Hohmann, Tim, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6plgbgnvm7jv7uo64orvfgntad