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Role of DJ-1 in Immune and Inflammatory Diseases

The DJ-1 protein, known as an oxidative stress sensor, participates in the onset of oxidative stress-related diseases such as cancer, neurodegenerative disorders, type 2 diabetes, and male infertility. Although DJ-1 has been extensively studied for more than two decades, evidence has only recently e...

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Autores principales: Zhang, Lulu, Wang, Jincheng, Wang, Jiajia, Yang, Bo, He, Qiaojun, Weng, Qinjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308417/
https://www.ncbi.nlm.nih.gov/pubmed/32612601
http://dx.doi.org/10.3389/fimmu.2020.00994
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author Zhang, Lulu
Wang, Jincheng
Wang, Jiajia
Yang, Bo
He, Qiaojun
Weng, Qinjie
author_facet Zhang, Lulu
Wang, Jincheng
Wang, Jiajia
Yang, Bo
He, Qiaojun
Weng, Qinjie
author_sort Zhang, Lulu
collection PubMed
description The DJ-1 protein, known as an oxidative stress sensor, participates in the onset of oxidative stress-related diseases such as cancer, neurodegenerative disorders, type 2 diabetes, and male infertility. Although DJ-1 has been extensively studied for more than two decades, evidence has only recently emerged that it plays a key role in immune and inflammatory disorders. The immune regulatory function of DJ-1 is achieved by modulating the activation of several immune cells including macrophages, mast cells, and T cells via reactive oxygen species (ROS)-dependent and/or ROS-independent mechanisms. This review describes the current knowledge on DJ-1, focusing on its immune and inflammatory regulatory roles, and highlights the significance of DJ-1 as a novel therapeutic target for immune and inflammatory diseases.
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spelling pubmed-73084172020-06-30 Role of DJ-1 in Immune and Inflammatory Diseases Zhang, Lulu Wang, Jincheng Wang, Jiajia Yang, Bo He, Qiaojun Weng, Qinjie Front Immunol Immunology The DJ-1 protein, known as an oxidative stress sensor, participates in the onset of oxidative stress-related diseases such as cancer, neurodegenerative disorders, type 2 diabetes, and male infertility. Although DJ-1 has been extensively studied for more than two decades, evidence has only recently emerged that it plays a key role in immune and inflammatory disorders. The immune regulatory function of DJ-1 is achieved by modulating the activation of several immune cells including macrophages, mast cells, and T cells via reactive oxygen species (ROS)-dependent and/or ROS-independent mechanisms. This review describes the current knowledge on DJ-1, focusing on its immune and inflammatory regulatory roles, and highlights the significance of DJ-1 as a novel therapeutic target for immune and inflammatory diseases. Frontiers Media S.A. 2020-06-16 /pmc/articles/PMC7308417/ /pubmed/32612601 http://dx.doi.org/10.3389/fimmu.2020.00994 Text en Copyright © 2020 Zhang, Wang, Wang, Yang, He and Weng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Lulu
Wang, Jincheng
Wang, Jiajia
Yang, Bo
He, Qiaojun
Weng, Qinjie
Role of DJ-1 in Immune and Inflammatory Diseases
title Role of DJ-1 in Immune and Inflammatory Diseases
title_full Role of DJ-1 in Immune and Inflammatory Diseases
title_fullStr Role of DJ-1 in Immune and Inflammatory Diseases
title_full_unstemmed Role of DJ-1 in Immune and Inflammatory Diseases
title_short Role of DJ-1 in Immune and Inflammatory Diseases
title_sort role of dj-1 in immune and inflammatory diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308417/
https://www.ncbi.nlm.nih.gov/pubmed/32612601
http://dx.doi.org/10.3389/fimmu.2020.00994
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