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Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate

Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism of genes encoding proteins engaged in the folate metabolism pathway. The aim of the curre...

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Detalles Bibliográficos
Autores principales:	Cwiklinska, Magdalena, Czogala, Malgorzata, Kwiecinska, Kinga, Madetko-Talowska, Anna, Szafarz, Malgorzata, Pawinska, Katarzyna, Wieczorek, Aleksandra, Klekawka, Tomasz, Rej, Magdalena, Stepien, Konrad, Halubiec, Przemyslaw, Lazarczyk, Agnieszka, Miklusiak, Karol, Bik-Multanowski, Miroslaw, Balwierz, Walentyna, Skoczen, Szymon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pediatrics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308427/ https://www.ncbi.nlm.nih.gov/pubmed/32612964 http://dx.doi.org/10.3389/fped.2020.00307

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