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Genital Micro-Organisms in Pregnancy

The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often lo...

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Detalles Bibliográficos
Autores principales: Bagga, Rashmi, Arora, Parul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308476/
https://www.ncbi.nlm.nih.gov/pubmed/32612969
http://dx.doi.org/10.3389/fpubh.2020.00225
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author Bagga, Rashmi
Arora, Parul
author_facet Bagga, Rashmi
Arora, Parul
author_sort Bagga, Rashmi
collection PubMed
description The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often low virulent infectious states lead to chronic inflammatory states and maybe associated with adverse maternal and neonatal outcome. Organisms have been isolated from amniotic fluid and placentae from women delivering pre-term; however the possibility of contamination cannot be conclusively ruled out. Common vaginal dysbiotic states often cause symptoms that are overlooked and often untreated. Vulvovaginal Candidiasis (VVC), Bacterial Vaginosis (BV), and Trichomonas Vaginitis (TV) are the commonly occurring dysbiotic states leading to vaginal infective states in pregnancy. With the advent of novel technologies like Next Generation sequencing (NGS), it will soon be possible to comprehensively map the vaginal microbiome and assess the interplay of each microbial state with their effects in pregnancy. This may open new avenues for antibiotic recommendations, probiotics and potential alternate therapies for dysbiotic states leading to pregnancy complications.
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spelling pubmed-73084762020-06-30 Genital Micro-Organisms in Pregnancy Bagga, Rashmi Arora, Parul Front Public Health Public Health The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often low virulent infectious states lead to chronic inflammatory states and maybe associated with adverse maternal and neonatal outcome. Organisms have been isolated from amniotic fluid and placentae from women delivering pre-term; however the possibility of contamination cannot be conclusively ruled out. Common vaginal dysbiotic states often cause symptoms that are overlooked and often untreated. Vulvovaginal Candidiasis (VVC), Bacterial Vaginosis (BV), and Trichomonas Vaginitis (TV) are the commonly occurring dysbiotic states leading to vaginal infective states in pregnancy. With the advent of novel technologies like Next Generation sequencing (NGS), it will soon be possible to comprehensively map the vaginal microbiome and assess the interplay of each microbial state with their effects in pregnancy. This may open new avenues for antibiotic recommendations, probiotics and potential alternate therapies for dysbiotic states leading to pregnancy complications. Frontiers Media S.A. 2020-06-16 /pmc/articles/PMC7308476/ /pubmed/32612969 http://dx.doi.org/10.3389/fpubh.2020.00225 Text en Copyright © 2020 Bagga and Arora. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Bagga, Rashmi
Arora, Parul
Genital Micro-Organisms in Pregnancy
title Genital Micro-Organisms in Pregnancy
title_full Genital Micro-Organisms in Pregnancy
title_fullStr Genital Micro-Organisms in Pregnancy
title_full_unstemmed Genital Micro-Organisms in Pregnancy
title_short Genital Micro-Organisms in Pregnancy
title_sort genital micro-organisms in pregnancy
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308476/
https://www.ncbi.nlm.nih.gov/pubmed/32612969
http://dx.doi.org/10.3389/fpubh.2020.00225
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