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Neuromechanisms of SARS-CoV-2: A Review
Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable corona...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308495/ https://www.ncbi.nlm.nih.gov/pubmed/32612515 http://dx.doi.org/10.3389/fnana.2020.00037 |
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author | DosSantos, Marcos F. Devalle, Sylvie Aran, Veronica Capra, Daniela Roque, Natália Roberta Coelho-Aguiar, Juliana de Mattos Spohr, Tânia Cristina Leite de Sampaio e Subilhaga, Janice Gonçalves Pereira, Cláudia Maria D'Andrea Meira, Isabella Niemeyer Soares Filho, Paulo Moura-Neto, Vivaldo |
author_facet | DosSantos, Marcos F. Devalle, Sylvie Aran, Veronica Capra, Daniela Roque, Natália Roberta Coelho-Aguiar, Juliana de Mattos Spohr, Tânia Cristina Leite de Sampaio e Subilhaga, Janice Gonçalves Pereira, Cláudia Maria D'Andrea Meira, Isabella Niemeyer Soares Filho, Paulo Moura-Neto, Vivaldo |
author_sort | DosSantos, Marcos F. |
collection | PubMed |
description | Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19. |
format | Online Article Text |
id | pubmed-7308495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73084952020-06-30 Neuromechanisms of SARS-CoV-2: A Review DosSantos, Marcos F. Devalle, Sylvie Aran, Veronica Capra, Daniela Roque, Natália Roberta Coelho-Aguiar, Juliana de Mattos Spohr, Tânia Cristina Leite de Sampaio e Subilhaga, Janice Gonçalves Pereira, Cláudia Maria D'Andrea Meira, Isabella Niemeyer Soares Filho, Paulo Moura-Neto, Vivaldo Front Neuroanat Neuroscience Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19. Frontiers Media S.A. 2020-06-16 /pmc/articles/PMC7308495/ /pubmed/32612515 http://dx.doi.org/10.3389/fnana.2020.00037 Text en Copyright © 2020 DosSantos, Devalle, Aran, Capra, Roque, Coelho-Aguiar, Spohr, Subilhaga, Pereira, D'Andrea Meira, Niemeyer Soares Filho and Moura-Neto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience DosSantos, Marcos F. Devalle, Sylvie Aran, Veronica Capra, Daniela Roque, Natália Roberta Coelho-Aguiar, Juliana de Mattos Spohr, Tânia Cristina Leite de Sampaio e Subilhaga, Janice Gonçalves Pereira, Cláudia Maria D'Andrea Meira, Isabella Niemeyer Soares Filho, Paulo Moura-Neto, Vivaldo Neuromechanisms of SARS-CoV-2: A Review |
title | Neuromechanisms of SARS-CoV-2: A Review |
title_full | Neuromechanisms of SARS-CoV-2: A Review |
title_fullStr | Neuromechanisms of SARS-CoV-2: A Review |
title_full_unstemmed | Neuromechanisms of SARS-CoV-2: A Review |
title_short | Neuromechanisms of SARS-CoV-2: A Review |
title_sort | neuromechanisms of sars-cov-2: a review |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308495/ https://www.ncbi.nlm.nih.gov/pubmed/32612515 http://dx.doi.org/10.3389/fnana.2020.00037 |
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