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Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the mechanism that defines how immunosuppressive...

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Detalles Bibliográficos
Autores principales:	Zhai, Lijie, Bell, April, Ladomersky, Erik, Lauing, Kristen L., Bollu, Lakshmi, Sosman, Jeffrey A., Zhang, Bin, Wu, Jennifer D., Miller, Stephen D., Meeks, Joshua J., Lukas, Rimas V., Wyatt, Eugene, Doglio, Lynn, Schiltz, Gary E., McCusker, Robert H., Wainwright, Derek A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308527/ https://www.ncbi.nlm.nih.gov/pubmed/32612606 http://dx.doi.org/10.3389/fimmu.2020.01185

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