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Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study
Background and Objective: Different metabolic phenotypes of obesity are related to cardiometabolic risk factors in children and adolescents. Vitamin D, as one important factor, could be related to different subgroups of metabolic obesity and might affect metabolic disorders. The purpose of this stud...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308554/ https://www.ncbi.nlm.nih.gov/pubmed/32612573 http://dx.doi.org/10.3389/fendo.2020.00310 |
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author | Esmaili, Haleh Heshmat, Ramin Ejtahed, Hanieh-Sadat Rastad, Hadith Motlagh, Mohammad Esmaeil Asayesh, Hamid Jafarnejad, Marzieh Seif, Ehsan Qorbani, Mostafa Kelishadi, Roya |
author_facet | Esmaili, Haleh Heshmat, Ramin Ejtahed, Hanieh-Sadat Rastad, Hadith Motlagh, Mohammad Esmaeil Asayesh, Hamid Jafarnejad, Marzieh Seif, Ehsan Qorbani, Mostafa Kelishadi, Roya |
author_sort | Esmaili, Haleh |
collection | PubMed |
description | Background and Objective: Different metabolic phenotypes of obesity are related to cardiometabolic risk factors in children and adolescents. Vitamin D, as one important factor, could be related to different subgroups of metabolic obesity and might affect metabolic disorders. The purpose of this study was to evaluate the relationship between serum 25-hydroxyvitamin D concentration and subsets of metabolic phenotypes of obesity in children and adolescents. Methods: This nationwide cross-sectional study was conducted in the framework of the fifth survey of a national surveillance program, the CASPIAN study. Overall, 2,594 students aged 7–18 years were assessed for 25-hydroxyvitamin D status. Metabolic syndrome (MetS) was defined according to the ATP III criteria modified for the pediatric age group. Participants were classified into four metabolic phenotypes of obesity according to categories of the BMI and metabolic status: “metabolically healthy obese” (MHO), “metabolically non-healthy non-obese” (MNHNO), “metabolically non-healthy obese” (MNHO), and “metabolically healthy non-obese” (MHNO). Multinomial logistic regression analysis was performed for evaluating the association of 25-hydroxyvitamin D status with different metabolic phenotypes of obesity. Results: In this study, 85.2% of participants were classified as MHNO, 11.0 % as MHO, 2.5% as MNHNO, and 1.3% as MNHO. The frequency of hypovitaminosis D was more prevalent in MNHO (85.3%) than in other phenotypes (MHNO: 70%; MHO: 76.5%; MNHNO: 78.1%, respectively; p < 0.05). In the multivariate model, hypovitaminosis D significantly increased the odds of being MHO (OR: 1.46; 95% CI: 1.07–1.77) and MNHO (OR: 2.89; 1.05–8.31) compared to the healthy group. Likewise, in multivariate model, per each unit (ng/mL) increment in 25-hydroxyvitamin D concentration, the odds of MNHNO and MNHO decreased significantly by 7% (OR: 0.93; 0.91–0.96) and 6% (OR: 0.94; 0.91–0.98) respectively. Conclusion: Our results support the hypothesis that 25-hydroxyvitamin D concentration is associated with metabolic obesity phenotypes. Longitudinal studies are necessary to assess the clinical impacts of this finding. |
format | Online Article Text |
id | pubmed-7308554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73085542020-06-30 Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study Esmaili, Haleh Heshmat, Ramin Ejtahed, Hanieh-Sadat Rastad, Hadith Motlagh, Mohammad Esmaeil Asayesh, Hamid Jafarnejad, Marzieh Seif, Ehsan Qorbani, Mostafa Kelishadi, Roya Front Endocrinol (Lausanne) Endocrinology Background and Objective: Different metabolic phenotypes of obesity are related to cardiometabolic risk factors in children and adolescents. Vitamin D, as one important factor, could be related to different subgroups of metabolic obesity and might affect metabolic disorders. The purpose of this study was to evaluate the relationship between serum 25-hydroxyvitamin D concentration and subsets of metabolic phenotypes of obesity in children and adolescents. Methods: This nationwide cross-sectional study was conducted in the framework of the fifth survey of a national surveillance program, the CASPIAN study. Overall, 2,594 students aged 7–18 years were assessed for 25-hydroxyvitamin D status. Metabolic syndrome (MetS) was defined according to the ATP III criteria modified for the pediatric age group. Participants were classified into four metabolic phenotypes of obesity according to categories of the BMI and metabolic status: “metabolically healthy obese” (MHO), “metabolically non-healthy non-obese” (MNHNO), “metabolically non-healthy obese” (MNHO), and “metabolically healthy non-obese” (MHNO). Multinomial logistic regression analysis was performed for evaluating the association of 25-hydroxyvitamin D status with different metabolic phenotypes of obesity. Results: In this study, 85.2% of participants were classified as MHNO, 11.0 % as MHO, 2.5% as MNHNO, and 1.3% as MNHO. The frequency of hypovitaminosis D was more prevalent in MNHO (85.3%) than in other phenotypes (MHNO: 70%; MHO: 76.5%; MNHNO: 78.1%, respectively; p < 0.05). In the multivariate model, hypovitaminosis D significantly increased the odds of being MHO (OR: 1.46; 95% CI: 1.07–1.77) and MNHO (OR: 2.89; 1.05–8.31) compared to the healthy group. Likewise, in multivariate model, per each unit (ng/mL) increment in 25-hydroxyvitamin D concentration, the odds of MNHNO and MNHO decreased significantly by 7% (OR: 0.93; 0.91–0.96) and 6% (OR: 0.94; 0.91–0.98) respectively. Conclusion: Our results support the hypothesis that 25-hydroxyvitamin D concentration is associated with metabolic obesity phenotypes. Longitudinal studies are necessary to assess the clinical impacts of this finding. Frontiers Media S.A. 2020-06-16 /pmc/articles/PMC7308554/ /pubmed/32612573 http://dx.doi.org/10.3389/fendo.2020.00310 Text en Copyright © 2020 Esmaili, Heshmat, Ejtahed, Rastad, Motlagh, Asayesh, Jafarnejad, Seif, Qorbani and Kelishadi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Esmaili, Haleh Heshmat, Ramin Ejtahed, Hanieh-Sadat Rastad, Hadith Motlagh, Mohammad Esmaeil Asayesh, Hamid Jafarnejad, Marzieh Seif, Ehsan Qorbani, Mostafa Kelishadi, Roya Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study |
title | Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study |
title_full | Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study |
title_fullStr | Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study |
title_full_unstemmed | Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study |
title_short | Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study |
title_sort | association of serum 25-hydroxyvitamin d level with metabolic phenotypes of obesity in children and adolescents: the caspian-v study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308554/ https://www.ncbi.nlm.nih.gov/pubmed/32612573 http://dx.doi.org/10.3389/fendo.2020.00310 |
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