The COVID-19 Cytokine Storm; What We Know So Far

COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the case...

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Autores principales: Ragab, Dina, Salah Eldin, Haitham, Taeimah, Mohamed, Khattab, Rasha, Salem, Ramy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308649/
https://www.ncbi.nlm.nih.gov/pubmed/32612617
http://dx.doi.org/10.3389/fimmu.2020.01446
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author Ragab, Dina
Salah Eldin, Haitham
Taeimah, Mohamed
Khattab, Rasha
Salem, Ramy
author_facet Ragab, Dina
Salah Eldin, Haitham
Taeimah, Mohamed
Khattab, Rasha
Salem, Ramy
author_sort Ragab, Dina
collection PubMed
description COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called “cytokine storm” induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality.
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spelling pubmed-73086492020-06-30 The COVID-19 Cytokine Storm; What We Know So Far Ragab, Dina Salah Eldin, Haitham Taeimah, Mohamed Khattab, Rasha Salem, Ramy Front Immunol Immunology COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called “cytokine storm” induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality. Frontiers Media S.A. 2020-06-16 /pmc/articles/PMC7308649/ /pubmed/32612617 http://dx.doi.org/10.3389/fimmu.2020.01446 Text en Copyright © 2020 Ragab, Salah Eldin, Taeimah, Khattab and Salem. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ragab, Dina
Salah Eldin, Haitham
Taeimah, Mohamed
Khattab, Rasha
Salem, Ramy
The COVID-19 Cytokine Storm; What We Know So Far
title The COVID-19 Cytokine Storm; What We Know So Far
title_full The COVID-19 Cytokine Storm; What We Know So Far
title_fullStr The COVID-19 Cytokine Storm; What We Know So Far
title_full_unstemmed The COVID-19 Cytokine Storm; What We Know So Far
title_short The COVID-19 Cytokine Storm; What We Know So Far
title_sort covid-19 cytokine storm; what we know so far
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308649/
https://www.ncbi.nlm.nih.gov/pubmed/32612617
http://dx.doi.org/10.3389/fimmu.2020.01446
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