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A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements

A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D planar array imaging sensor with spectroscopic measurements in a wide range...

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Detalles Bibliográficos
Autores principales: Ma, Gege, Soleimani, Manuchehr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308860/
https://www.ncbi.nlm.nih.gov/pubmed/32545282
http://dx.doi.org/10.3390/s20113327
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author Ma, Gege
Soleimani, Manuchehr
author_facet Ma, Gege
Soleimani, Manuchehr
author_sort Ma, Gege
collection PubMed
description A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D planar array imaging sensor with spectroscopic measurements in a wide range from low frequency to radiofrequency. Both these two setups are well suited for standard containers used in cell and culture biological studies, allowing for fully non-invasive testing. This is true as the capacitive based imaging sensor can extract dielectric spectroscopic images from the sample without direct contact with the medium. The paper shows the concept by deriving a wide range of spectroscopic information from biological test samples. We drive both spectra of electrical conductivity and the change rate of electrical conductivity with frequency as a piece of fundamentally important information. The high-frequency excitation allows the interrogation of critical properties that arise from the cell nucleus.
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spelling pubmed-73088602020-06-25 A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements Ma, Gege Soleimani, Manuchehr Sensors (Basel) Article A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D planar array imaging sensor with spectroscopic measurements in a wide range from low frequency to radiofrequency. Both these two setups are well suited for standard containers used in cell and culture biological studies, allowing for fully non-invasive testing. This is true as the capacitive based imaging sensor can extract dielectric spectroscopic images from the sample without direct contact with the medium. The paper shows the concept by deriving a wide range of spectroscopic information from biological test samples. We drive both spectra of electrical conductivity and the change rate of electrical conductivity with frequency as a piece of fundamentally important information. The high-frequency excitation allows the interrogation of critical properties that arise from the cell nucleus. MDPI 2020-06-11 /pmc/articles/PMC7308860/ /pubmed/32545282 http://dx.doi.org/10.3390/s20113327 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Gege
Soleimani, Manuchehr
A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
title A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
title_full A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
title_fullStr A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
title_full_unstemmed A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
title_short A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
title_sort new label-free and contactless bio-tomographic imaging with miniaturized capacitively-coupled spectroscopy measurements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308860/
https://www.ncbi.nlm.nih.gov/pubmed/32545282
http://dx.doi.org/10.3390/s20113327
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