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A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements
A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D planar array imaging sensor with spectroscopic measurements in a wide range...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308860/ https://www.ncbi.nlm.nih.gov/pubmed/32545282 http://dx.doi.org/10.3390/s20113327 |
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author | Ma, Gege Soleimani, Manuchehr |
author_facet | Ma, Gege Soleimani, Manuchehr |
author_sort | Ma, Gege |
collection | PubMed |
description | A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D planar array imaging sensor with spectroscopic measurements in a wide range from low frequency to radiofrequency. Both these two setups are well suited for standard containers used in cell and culture biological studies, allowing for fully non-invasive testing. This is true as the capacitive based imaging sensor can extract dielectric spectroscopic images from the sample without direct contact with the medium. The paper shows the concept by deriving a wide range of spectroscopic information from biological test samples. We drive both spectra of electrical conductivity and the change rate of electrical conductivity with frequency as a piece of fundamentally important information. The high-frequency excitation allows the interrogation of critical properties that arise from the cell nucleus. |
format | Online Article Text |
id | pubmed-7308860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73088602020-06-25 A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements Ma, Gege Soleimani, Manuchehr Sensors (Basel) Article A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D planar array imaging sensor with spectroscopic measurements in a wide range from low frequency to radiofrequency. Both these two setups are well suited for standard containers used in cell and culture biological studies, allowing for fully non-invasive testing. This is true as the capacitive based imaging sensor can extract dielectric spectroscopic images from the sample without direct contact with the medium. The paper shows the concept by deriving a wide range of spectroscopic information from biological test samples. We drive both spectra of electrical conductivity and the change rate of electrical conductivity with frequency as a piece of fundamentally important information. The high-frequency excitation allows the interrogation of critical properties that arise from the cell nucleus. MDPI 2020-06-11 /pmc/articles/PMC7308860/ /pubmed/32545282 http://dx.doi.org/10.3390/s20113327 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ma, Gege Soleimani, Manuchehr A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements |
title | A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements |
title_full | A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements |
title_fullStr | A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements |
title_full_unstemmed | A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements |
title_short | A New Label-Free and Contactless Bio-Tomographic Imaging with Miniaturized Capacitively-Coupled Spectroscopy Measurements |
title_sort | new label-free and contactless bio-tomographic imaging with miniaturized capacitively-coupled spectroscopy measurements |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308860/ https://www.ncbi.nlm.nih.gov/pubmed/32545282 http://dx.doi.org/10.3390/s20113327 |
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