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A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant

Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first...

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Autores principales: Lagousi, Theano, Korovessi, Paraskevi, Panagouli, Eleni, Tsagris, Vasilis, Kostaridou, Stavroula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308916/
https://www.ncbi.nlm.nih.gov/pubmed/32596066
http://dx.doi.org/10.7759/cureus.8246
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author Lagousi, Theano
Korovessi, Paraskevi
Panagouli, Eleni
Tsagris, Vasilis
Kostaridou, Stavroula
author_facet Lagousi, Theano
Korovessi, Paraskevi
Panagouli, Eleni
Tsagris, Vasilis
Kostaridou, Stavroula
author_sort Lagousi, Theano
collection PubMed
description Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first child of unrelated, healthy parents, with no significant medical history or unexplained infant death in the family, otherwise healthy, who was diagnosed with measles-associated HLH and was successfully treated with IV dexamethasone and IV immunoglobulin (IVIG). Additionally, we review previously reported cases of HLH secondary to measles and highlight the diagnostic and therapeutic challenges associated with its early recognition and treatment. High suspicion, early recognition, and appropriate treatment are essential for a favorable outcome of measles-associated HLH.
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spelling pubmed-73089162020-06-25 A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant Lagousi, Theano Korovessi, Paraskevi Panagouli, Eleni Tsagris, Vasilis Kostaridou, Stavroula Cureus Pediatrics Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first child of unrelated, healthy parents, with no significant medical history or unexplained infant death in the family, otherwise healthy, who was diagnosed with measles-associated HLH and was successfully treated with IV dexamethasone and IV immunoglobulin (IVIG). Additionally, we review previously reported cases of HLH secondary to measles and highlight the diagnostic and therapeutic challenges associated with its early recognition and treatment. High suspicion, early recognition, and appropriate treatment are essential for a favorable outcome of measles-associated HLH. Cureus 2020-05-23 /pmc/articles/PMC7308916/ /pubmed/32596066 http://dx.doi.org/10.7759/cureus.8246 Text en Copyright © 2020, Lagousi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Lagousi, Theano
Korovessi, Paraskevi
Panagouli, Eleni
Tsagris, Vasilis
Kostaridou, Stavroula
A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
title A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
title_full A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
title_fullStr A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
title_full_unstemmed A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
title_short A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
title_sort rare case of measles-associated hemophagocytic lymphohistiocytosis in an infant
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308916/
https://www.ncbi.nlm.nih.gov/pubmed/32596066
http://dx.doi.org/10.7759/cureus.8246
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