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A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant
Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308916/ https://www.ncbi.nlm.nih.gov/pubmed/32596066 http://dx.doi.org/10.7759/cureus.8246 |
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author | Lagousi, Theano Korovessi, Paraskevi Panagouli, Eleni Tsagris, Vasilis Kostaridou, Stavroula |
author_facet | Lagousi, Theano Korovessi, Paraskevi Panagouli, Eleni Tsagris, Vasilis Kostaridou, Stavroula |
author_sort | Lagousi, Theano |
collection | PubMed |
description | Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first child of unrelated, healthy parents, with no significant medical history or unexplained infant death in the family, otherwise healthy, who was diagnosed with measles-associated HLH and was successfully treated with IV dexamethasone and IV immunoglobulin (IVIG). Additionally, we review previously reported cases of HLH secondary to measles and highlight the diagnostic and therapeutic challenges associated with its early recognition and treatment. High suspicion, early recognition, and appropriate treatment are essential for a favorable outcome of measles-associated HLH. |
format | Online Article Text |
id | pubmed-7308916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-73089162020-06-25 A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant Lagousi, Theano Korovessi, Paraskevi Panagouli, Eleni Tsagris, Vasilis Kostaridou, Stavroula Cureus Pediatrics Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first child of unrelated, healthy parents, with no significant medical history or unexplained infant death in the family, otherwise healthy, who was diagnosed with measles-associated HLH and was successfully treated with IV dexamethasone and IV immunoglobulin (IVIG). Additionally, we review previously reported cases of HLH secondary to measles and highlight the diagnostic and therapeutic challenges associated with its early recognition and treatment. High suspicion, early recognition, and appropriate treatment are essential for a favorable outcome of measles-associated HLH. Cureus 2020-05-23 /pmc/articles/PMC7308916/ /pubmed/32596066 http://dx.doi.org/10.7759/cureus.8246 Text en Copyright © 2020, Lagousi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pediatrics Lagousi, Theano Korovessi, Paraskevi Panagouli, Eleni Tsagris, Vasilis Kostaridou, Stavroula A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant |
title | A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant |
title_full | A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant |
title_fullStr | A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant |
title_full_unstemmed | A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant |
title_short | A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant |
title_sort | rare case of measles-associated hemophagocytic lymphohistiocytosis in an infant |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308916/ https://www.ncbi.nlm.nih.gov/pubmed/32596066 http://dx.doi.org/10.7759/cureus.8246 |
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