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Is the oral cavity relevant in SARS-CoV-2 pandemic?

OBJECTIVES: Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS: A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS: Oral v...

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Detalles Bibliográficos
Autores principales: Herrera, David, Serrano, Jorge, Roldán, Silvia, Sanz, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309196/
https://www.ncbi.nlm.nih.gov/pubmed/32577830
http://dx.doi.org/10.1007/s00784-020-03413-2
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author Herrera, David
Serrano, Jorge
Roldán, Silvia
Sanz, Mariano
author_facet Herrera, David
Serrano, Jorge
Roldán, Silvia
Sanz, Mariano
author_sort Herrera, David
collection PubMed
description OBJECTIVES: Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS: A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS: Oral viral load of SARS-CoV-2 has been associated with the severity of COVID-19, and thus, a reduction in the oral viral load could be associated with a decrease in the severity of the condition. Similarly, a decrease in the oral viral load would diminish the amount of virus expelled and reduce the risk of transmission, since (i) during the first 10 days, the virus mainly accumulates at the nasal, oral, and pharyngeal area; (ii) the number of angiotensin-converting enzyme (ACE2) receptor is greater in the salivary glands as compared with the lungs; and (iii) salivary droplets represent the most relevant transmission route. To reduce the oral viral load, antiseptic agents may be used, although the evidence on its efficacy is indirect and weak. CONCLUSIONS: Antiseptic mouth rinses, such as those containing cetylpyridinium chloride or povidone-iodine, may be able to decrease the severity of COVID-19 by reducing oral viral load in infected subjects and decreasing the risk of transmission by limiting viral load in droplets, generated in normal life, or in aerosols, produced during dental procedures. Well-designed clinical and preclinical research must be conducted to support these hypotheses. CLINICAL RELEVANCE: Antiseptic mouth rinses may help in decreasing the severity of COVID-19 and in reducing the risk of transmission.
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spelling pubmed-73091962020-06-23 Is the oral cavity relevant in SARS-CoV-2 pandemic? Herrera, David Serrano, Jorge Roldán, Silvia Sanz, Mariano Clin Oral Investig Discussion Paper OBJECTIVES: Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS: A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS: Oral viral load of SARS-CoV-2 has been associated with the severity of COVID-19, and thus, a reduction in the oral viral load could be associated with a decrease in the severity of the condition. Similarly, a decrease in the oral viral load would diminish the amount of virus expelled and reduce the risk of transmission, since (i) during the first 10 days, the virus mainly accumulates at the nasal, oral, and pharyngeal area; (ii) the number of angiotensin-converting enzyme (ACE2) receptor is greater in the salivary glands as compared with the lungs; and (iii) salivary droplets represent the most relevant transmission route. To reduce the oral viral load, antiseptic agents may be used, although the evidence on its efficacy is indirect and weak. CONCLUSIONS: Antiseptic mouth rinses, such as those containing cetylpyridinium chloride or povidone-iodine, may be able to decrease the severity of COVID-19 by reducing oral viral load in infected subjects and decreasing the risk of transmission by limiting viral load in droplets, generated in normal life, or in aerosols, produced during dental procedures. Well-designed clinical and preclinical research must be conducted to support these hypotheses. CLINICAL RELEVANCE: Antiseptic mouth rinses may help in decreasing the severity of COVID-19 and in reducing the risk of transmission. Springer Berlin Heidelberg 2020-06-23 2020 /pmc/articles/PMC7309196/ /pubmed/32577830 http://dx.doi.org/10.1007/s00784-020-03413-2 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Discussion Paper
Herrera, David
Serrano, Jorge
Roldán, Silvia
Sanz, Mariano
Is the oral cavity relevant in SARS-CoV-2 pandemic?
title Is the oral cavity relevant in SARS-CoV-2 pandemic?
title_full Is the oral cavity relevant in SARS-CoV-2 pandemic?
title_fullStr Is the oral cavity relevant in SARS-CoV-2 pandemic?
title_full_unstemmed Is the oral cavity relevant in SARS-CoV-2 pandemic?
title_short Is the oral cavity relevant in SARS-CoV-2 pandemic?
title_sort is the oral cavity relevant in sars-cov-2 pandemic?
topic Discussion Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309196/
https://www.ncbi.nlm.nih.gov/pubmed/32577830
http://dx.doi.org/10.1007/s00784-020-03413-2
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