Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts

[Image: see text] A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible...

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Autores principales: Neerbye Berntsen, Linn, Nova, Ainara, Wragg, David S., Sandtorv, Alexander H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309330/
https://www.ncbi.nlm.nih.gov/pubmed/32202123
http://dx.doi.org/10.1021/acs.orglett.0c00642
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author Neerbye Berntsen, Linn
Nova, Ainara
Wragg, David S.
Sandtorv, Alexander H.
author_facet Neerbye Berntsen, Linn
Nova, Ainara
Wragg, David S.
Sandtorv, Alexander H.
author_sort Neerbye Berntsen, Linn
collection PubMed
description [Image: see text] A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.
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spelling pubmed-73093302020-06-23 Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts Neerbye Berntsen, Linn Nova, Ainara Wragg, David S. Sandtorv, Alexander H. Org Lett [Image: see text] A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins. American Chemical Society 2020-03-23 2020-04-03 /pmc/articles/PMC7309330/ /pubmed/32202123 http://dx.doi.org/10.1021/acs.orglett.0c00642 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Neerbye Berntsen, Linn
Nova, Ainara
Wragg, David S.
Sandtorv, Alexander H.
Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
title Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
title_full Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
title_fullStr Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
title_full_unstemmed Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
title_short Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
title_sort cu-catalyzed n-3-arylation of hydantoins using diaryliodonium salts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309330/
https://www.ncbi.nlm.nih.gov/pubmed/32202123
http://dx.doi.org/10.1021/acs.orglett.0c00642
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