GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease....

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Autores principales: Lang, Frederick M., Lee, Kevin M.-C., Teijaro, John R., Becher, Burkhard, Hamilton, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309428/
https://www.ncbi.nlm.nih.gov/pubmed/32576980
http://dx.doi.org/10.1038/s41577-020-0357-7
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author Lang, Frederick M.
Lee, Kevin M.-C.
Teijaro, John R.
Becher, Burkhard
Hamilton, John A.
author_facet Lang, Frederick M.
Lee, Kevin M.-C.
Teijaro, John R.
Becher, Burkhard
Hamilton, John A.
author_sort Lang, Frederick M.
collection PubMed
description Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits behind these contrasting approaches.
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spelling pubmed-73094282020-06-23 GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches Lang, Frederick M. Lee, Kevin M.-C. Teijaro, John R. Becher, Burkhard Hamilton, John A. Nat Rev Immunol Perspective Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits behind these contrasting approaches. Nature Publishing Group UK 2020-06-23 2020 /pmc/articles/PMC7309428/ /pubmed/32576980 http://dx.doi.org/10.1038/s41577-020-0357-7 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Perspective
Lang, Frederick M.
Lee, Kevin M.-C.
Teijaro, John R.
Becher, Burkhard
Hamilton, John A.
GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
title GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
title_full GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
title_fullStr GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
title_full_unstemmed GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
title_short GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
title_sort gm-csf-based treatments in covid-19: reconciling opposing therapeutic approaches
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309428/
https://www.ncbi.nlm.nih.gov/pubmed/32576980
http://dx.doi.org/10.1038/s41577-020-0357-7
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