Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) has been shown to be critical for the development of breast cancer stem cells. Here we show that circulating tumor cells isolated...

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Detalles Bibliográficos
Autores principales: Tu, Wen Juan, McCuaig, Robert D., Tan, Abel H. Y., Hardy, Kristine, Seddiki, Nabila, Ali, Sayed, Dahlstrom, Jane E., Bean, Elaine G., Dunn, Jenny, Forwood, Jade, Tsimbalyuk, Sofia, Smith, Kate, Yip, Desmond, Malik, Laeeq, Prasanna, Thiru, Milburn, Peter, Rao, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309504/
https://www.ncbi.nlm.nih.gov/pubmed/32612611
http://dx.doi.org/10.3389/fimmu.2020.01228

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