Generation of human induced pluripotent stem cells (NIHTVBi004-A, NIHTVBi005-A, NIHTVBi006-A, NIHTVBi007-A, NIHTVBi008-A) from 5 CADASIL patients with NOTCH3 mutation

We have successfully generated induced pluripotent stem cell (iPSC) lines derived from peripheral blood mononuclear cells of five patients with Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). These cells carry the genetic NOTCH3 mutation present...

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Detalles Bibliográficos
Autores principales: Chen, Guibin, Li, Zhongwen, Liu, Yangtengyu, Chen, Daniel, Beers, Jeanette, Cudrici, Cornelia, Ferrante, Elisa A., Schwartzbeck, Robin, Dmitrieva, Natalia, Yang, Dan, Zou, Jizhong, Iruela-Arispe, M. Luisa, Boehm, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309701/
https://www.ncbi.nlm.nih.gov/pubmed/32344328
http://dx.doi.org/10.1016/j.scr.2020.101821
Descripción
Sumario:We have successfully generated induced pluripotent stem cell (iPSC) lines derived from peripheral blood mononuclear cells of five patients with Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). These cells carry the genetic NOTCH3 mutation present in their parental cells. These iPSC cells exhibited normal karyotype and phenotype, which were sustained through propagation. Furthermore, these iPSCs displayed the capacity of differentiating toward the three germ layers in vitro.

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