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Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome

BACKGROUND: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS). MATERIALS AND METHODS: In this prospective observational study, a total of 30 patients with OHS, who were subjected to BIPAP therapy, w...

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Detalles Bibliográficos
Autores principales: Amra, Babak, Samadi, Behrooz, Soltaninejad, Forogh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309893/
https://www.ncbi.nlm.nih.gov/pubmed/32607112
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author Amra, Babak
Samadi, Behrooz
Soltaninejad, Forogh
author_facet Amra, Babak
Samadi, Behrooz
Soltaninejad, Forogh
author_sort Amra, Babak
collection PubMed
description BACKGROUND: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS). MATERIALS AND METHODS: In this prospective observational study, a total of 30 patients with OHS, who were subjected to BIPAP therapy, were included. The peripheral capillary oxygen saturation (SPO(2)), partial pressure of carbon dioxide (PCO(2)), body mass index (BMI), and body composition indices, including total body fat (TBF), total body protein (TBP), total body mineral (TBM), and total body water (TBW), were measured using standard procedures at baseline and one week, one month, and six months after the onset of treatment. Changes in the variables over time were evaluated using repeated measures analysis of variance (ANOVA). The correlation between changes in the body composition indices and changes in gas exchange was also assessed by Pearson’s correlation coefficient test at three time points from the baseline. RESULTS: The results revealed that all study variables, except for TBF, changed significantly during the study in both males and females (P<0.001). There was a significant positive association between changes in PCO(2) and changes in TBM after six months (r=0.4, P<0.05), whereas a significant inverse correlation was found between changes in PCO(2) and changes in TBW after six months (r=−0.39, P<0.05). However, no significant correlation was found between changes in gas exchange and changes in BMI or other body composition indices after six months. CONCLUSION: The present results indicated no significant association between the improvement of gas exchange and changes in BMI, TBP, and TBF during the study. However, further large-scale studies are required to examine the effects of BIPAP therapy on body composition in patients with OHS.
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spelling pubmed-73098932020-06-29 Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome Amra, Babak Samadi, Behrooz Soltaninejad, Forogh Tanaffos Original Article BACKGROUND: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS). MATERIALS AND METHODS: In this prospective observational study, a total of 30 patients with OHS, who were subjected to BIPAP therapy, were included. The peripheral capillary oxygen saturation (SPO(2)), partial pressure of carbon dioxide (PCO(2)), body mass index (BMI), and body composition indices, including total body fat (TBF), total body protein (TBP), total body mineral (TBM), and total body water (TBW), were measured using standard procedures at baseline and one week, one month, and six months after the onset of treatment. Changes in the variables over time were evaluated using repeated measures analysis of variance (ANOVA). The correlation between changes in the body composition indices and changes in gas exchange was also assessed by Pearson’s correlation coefficient test at three time points from the baseline. RESULTS: The results revealed that all study variables, except for TBF, changed significantly during the study in both males and females (P<0.001). There was a significant positive association between changes in PCO(2) and changes in TBM after six months (r=0.4, P<0.05), whereas a significant inverse correlation was found between changes in PCO(2) and changes in TBW after six months (r=−0.39, P<0.05). However, no significant correlation was found between changes in gas exchange and changes in BMI or other body composition indices after six months. CONCLUSION: The present results indicated no significant association between the improvement of gas exchange and changes in BMI, TBP, and TBF during the study. However, further large-scale studies are required to examine the effects of BIPAP therapy on body composition in patients with OHS. National Research Institute of Tuberculosis and Lung Disease 2019-04 /pmc/articles/PMC7309893/ /pubmed/32607112 Text en Copyright© 2019 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Amra, Babak
Samadi, Behrooz
Soltaninejad, Forogh
Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome
title Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome
title_full Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome
title_fullStr Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome
title_full_unstemmed Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome
title_short Effect of Bi-Level Positive Airway Pressure (BIPAP) Ventilation on Gas Exchange, Body Mass Index, and Body Composition in Patients with Obesity Hypoventilation Syndrome
title_sort effect of bi-level positive airway pressure (bipap) ventilation on gas exchange, body mass index, and body composition in patients with obesity hypoventilation syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309893/
https://www.ncbi.nlm.nih.gov/pubmed/32607112
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