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Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula

BACKGROUND: Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perfo...

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Autores principales: Wan, Zi-ming, Hu, Bo, Lai, Qi-quan, Gao, Xue-jing, Tu, Bo, Zhou, Yu, Zhao, Wen-bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310035/
https://www.ncbi.nlm.nih.gov/pubmed/32571240
http://dx.doi.org/10.1186/s12882-020-01883-w
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author Wan, Zi-ming
Hu, Bo
Lai, Qi-quan
Gao, Xue-jing
Tu, Bo
Zhou, Yu
Zhao, Wen-bo
author_facet Wan, Zi-ming
Hu, Bo
Lai, Qi-quan
Gao, Xue-jing
Tu, Bo
Zhou, Yu
Zhao, Wen-bo
author_sort Wan, Zi-ming
collection PubMed
description BACKGROUND: Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to assess these aspects. METHODS: Our retrospective cohort study enrolled and analyzed 353 follow-up cases that underwent first AVF creation. The artery and vein sizes were measured by ultrasound. We performed follow-up, a minimum of 3 months after surgery. Multivariable logistic regression analysis was used to identify independent risk factors inmaturation. Participant age was categorized into four groups (age ≤ 29, 30–49, 50–69, and 70–90 years). Radial artery diameter was categorized into four groups (≤ 1.9, >1.9 and ≤ 2.1, >2.1 and ≤ 2.4, >2.4 mm) according to median and interquartile ranges. We adjusted for confounders in four logistic models, and primary analyses were based on building ordered category models and tested P values for trends to estimate the relationship of radial artery diameter and each 20-year increase in age with risk of maturation. RESULTS: The mature RCAVF group included 301 cases, and the immature group included 52 cases. Radial artery diameter, age, and diabetes were independent risk factors of maturation. Odds ratios (ORs) associated with maturation reduced with increasing age, while ORs increased with increasing radial artery diameter. P values for trends(<0.05) were observed in all four models. A reduction in radial artery diameter and higher age were significantly associated with a higher incidence of immaturity after adjusting the multivariate models. The risks of immaturation were increased by more than 1.54 fold for each 20-year increase and increased by more than 1.34 fold for the smaller radial artery diameter group. CONCLUSION: Our findings suggest that a significantly higher immaturity risk of RCAVF was associated with increasing age and a reduction in radial artery diameter. Our study identified a linear exposure-response relationship of age and radial artery diameter with immaturity incident. A careful selection of patients will be helpful in improving AVF functional maturation.
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spelling pubmed-73100352020-06-23 Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula Wan, Zi-ming Hu, Bo Lai, Qi-quan Gao, Xue-jing Tu, Bo Zhou, Yu Zhao, Wen-bo BMC Nephrol Research Article BACKGROUND: Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to assess these aspects. METHODS: Our retrospective cohort study enrolled and analyzed 353 follow-up cases that underwent first AVF creation. The artery and vein sizes were measured by ultrasound. We performed follow-up, a minimum of 3 months after surgery. Multivariable logistic regression analysis was used to identify independent risk factors inmaturation. Participant age was categorized into four groups (age ≤ 29, 30–49, 50–69, and 70–90 years). Radial artery diameter was categorized into four groups (≤ 1.9, >1.9 and ≤ 2.1, >2.1 and ≤ 2.4, >2.4 mm) according to median and interquartile ranges. We adjusted for confounders in four logistic models, and primary analyses were based on building ordered category models and tested P values for trends to estimate the relationship of radial artery diameter and each 20-year increase in age with risk of maturation. RESULTS: The mature RCAVF group included 301 cases, and the immature group included 52 cases. Radial artery diameter, age, and diabetes were independent risk factors of maturation. Odds ratios (ORs) associated with maturation reduced with increasing age, while ORs increased with increasing radial artery diameter. P values for trends(<0.05) were observed in all four models. A reduction in radial artery diameter and higher age were significantly associated with a higher incidence of immaturity after adjusting the multivariate models. The risks of immaturation were increased by more than 1.54 fold for each 20-year increase and increased by more than 1.34 fold for the smaller radial artery diameter group. CONCLUSION: Our findings suggest that a significantly higher immaturity risk of RCAVF was associated with increasing age and a reduction in radial artery diameter. Our study identified a linear exposure-response relationship of age and radial artery diameter with immaturity incident. A careful selection of patients will be helpful in improving AVF functional maturation. BioMed Central 2020-06-22 /pmc/articles/PMC7310035/ /pubmed/32571240 http://dx.doi.org/10.1186/s12882-020-01883-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Wan, Zi-ming
Hu, Bo
Lai, Qi-quan
Gao, Xue-jing
Tu, Bo
Zhou, Yu
Zhao, Wen-bo
Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
title Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
title_full Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
title_fullStr Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
title_full_unstemmed Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
title_short Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
title_sort radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310035/
https://www.ncbi.nlm.nih.gov/pubmed/32571240
http://dx.doi.org/10.1186/s12882-020-01883-w
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