FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1

BACKGROUND: Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, little is known about the mechanism of HSP90AA1 regulation. METHODS: Transcriptome RNA-sequencing data of hepato...

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Detalles Bibliográficos
Autores principales: Shi, Weidong, Feng, Lanyun, Dong, Shu, Ning, Zhouyu, Hua, Yongqiang, Liu, Luming, Chen, Zhen, Meng, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310287/
https://www.ncbi.nlm.nih.gov/pubmed/32576198
http://dx.doi.org/10.1186/s12964-020-00604-y

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