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Identification of plasmid IncQ1 and NTE(KPC)-IId harboring bla (KPC-2) in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil
INTRODUCTION: This study investigated the genetic environment of bla (KPC-2) in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODS: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using poly...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Medicina Tropical - SBMT
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310361/ https://www.ncbi.nlm.nih.gov/pubmed/32578705 http://dx.doi.org/10.1590/0037-8682-0526-2019 |
Sumario: | INTRODUCTION: This study investigated the genetic environment of bla (KPC-2) in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODS: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing. RESULTS: The bla (KPC-2) gene was located between ISKpn6 and a resolvase tnpR in the non-Tn4401 element (NTE(KPC-)IId). It was detected on a plasmid belonging to the IncQ1 group. CONCLUSIONS: To our knowledge, this is the first report of the presence of the bla (KPC-2) gene in the NTE(KPC)-IId element carried by plasmid IncQ1 from infections in Brazil. |
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