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Association of cerebral malaria and TNF-α levels: a systematic review

BACKGROUND: Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria. METHODS: This review followed the Preferred Reporting o...

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Autores principales: Leão, Luana, Puty, Bruna, Dolabela, Maria Fâni, Povoa, Marinete Marins, Né, Yago Gecy De Sousa, Eiró, Luciana Guimarães, Fagundes, Nathália Carolina Fernandes, Maia, Lucianne Cople, Lima, Rafael Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310527/
https://www.ncbi.nlm.nih.gov/pubmed/32576141
http://dx.doi.org/10.1186/s12879-020-05107-2
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author Leão, Luana
Puty, Bruna
Dolabela, Maria Fâni
Povoa, Marinete Marins
Né, Yago Gecy De Sousa
Eiró, Luciana Guimarães
Fagundes, Nathália Carolina Fernandes
Maia, Lucianne Cople
Lima, Rafael Rodrigues
author_facet Leão, Luana
Puty, Bruna
Dolabela, Maria Fâni
Povoa, Marinete Marins
Né, Yago Gecy De Sousa
Eiró, Luciana Guimarães
Fagundes, Nathália Carolina Fernandes
Maia, Lucianne Cople
Lima, Rafael Rodrigues
author_sort Leão, Luana
collection PubMed
description BACKGROUND: Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria. METHODS: This review followed the Preferred Reporting of Systematic Review and Meta-analyses (PRISMA) guidelines. The search was performed at PubMed, LILACS, Scopus, Web of Science, The Cochrane Library, OpenGrey and Google Scholar. We have included studies of P. falciparum-infected humans with or without cerebral malaria and TNF-α dosage level. All studies were evaluated using a risk of bias tool and the GRADE approach. RESULTS: Our results have identified 2338 studies, and 8 articles were eligible according to this systematic review inclusion criteria. Among the eight articles, five have evaluated TNF- α plasma dosage, while two have evaluated at the blood and one at the brain (post-Morten). Among them, only five studies showed higher TNF-α levels in the cerebral malaria group compared to the severe malaria group. Methodological problems were identified regarding sample size, randomization and blindness, but no risk of bias was detected. CONCLUSION: Although the results suggested that that TNF-α level is associated with cerebral malaria, the evidence is inconsistent and imprecise. More observational studies evaluating the average TNF-alpha are needed.
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spelling pubmed-73105272020-06-24 Association of cerebral malaria and TNF-α levels: a systematic review Leão, Luana Puty, Bruna Dolabela, Maria Fâni Povoa, Marinete Marins Né, Yago Gecy De Sousa Eiró, Luciana Guimarães Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues BMC Infect Dis Research Article BACKGROUND: Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria. METHODS: This review followed the Preferred Reporting of Systematic Review and Meta-analyses (PRISMA) guidelines. The search was performed at PubMed, LILACS, Scopus, Web of Science, The Cochrane Library, OpenGrey and Google Scholar. We have included studies of P. falciparum-infected humans with or without cerebral malaria and TNF-α dosage level. All studies were evaluated using a risk of bias tool and the GRADE approach. RESULTS: Our results have identified 2338 studies, and 8 articles were eligible according to this systematic review inclusion criteria. Among the eight articles, five have evaluated TNF- α plasma dosage, while two have evaluated at the blood and one at the brain (post-Morten). Among them, only five studies showed higher TNF-α levels in the cerebral malaria group compared to the severe malaria group. Methodological problems were identified regarding sample size, randomization and blindness, but no risk of bias was detected. CONCLUSION: Although the results suggested that that TNF-α level is associated with cerebral malaria, the evidence is inconsistent and imprecise. More observational studies evaluating the average TNF-alpha are needed. BioMed Central 2020-06-23 /pmc/articles/PMC7310527/ /pubmed/32576141 http://dx.doi.org/10.1186/s12879-020-05107-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Leão, Luana
Puty, Bruna
Dolabela, Maria Fâni
Povoa, Marinete Marins
Né, Yago Gecy De Sousa
Eiró, Luciana Guimarães
Fagundes, Nathália Carolina Fernandes
Maia, Lucianne Cople
Lima, Rafael Rodrigues
Association of cerebral malaria and TNF-α levels: a systematic review
title Association of cerebral malaria and TNF-α levels: a systematic review
title_full Association of cerebral malaria and TNF-α levels: a systematic review
title_fullStr Association of cerebral malaria and TNF-α levels: a systematic review
title_full_unstemmed Association of cerebral malaria and TNF-α levels: a systematic review
title_short Association of cerebral malaria and TNF-α levels: a systematic review
title_sort association of cerebral malaria and tnf-α levels: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310527/
https://www.ncbi.nlm.nih.gov/pubmed/32576141
http://dx.doi.org/10.1186/s12879-020-05107-2
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