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Electro-oculography in bilateral optic neuropathy

OBJECTIVE: Effect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light peak and dark trough values of electro-oculogra...

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Autores principales: Dahanayake, Padmini, Dassanayake, Tharaka L., Pathirage, Manoji, Senanayake, Saman, Sedgwick, Mike, Weerasinghe, Vajira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310542/
https://www.ncbi.nlm.nih.gov/pubmed/32571391
http://dx.doi.org/10.1186/s13104-020-05131-0
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author Dahanayake, Padmini
Dassanayake, Tharaka L.
Pathirage, Manoji
Senanayake, Saman
Sedgwick, Mike
Weerasinghe, Vajira
author_facet Dahanayake, Padmini
Dassanayake, Tharaka L.
Pathirage, Manoji
Senanayake, Saman
Sedgwick, Mike
Weerasinghe, Vajira
author_sort Dahanayake, Padmini
collection PubMed
description OBJECTIVE: Effect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light peak and dark trough values of electro-oculography. Thirty-seven patients with a clinical diagnosis of bilateral optic neuropathy and 40 control subjects were recruited in this observational, cross-sectional study, carried out at the Neurophysiology unit, Teaching Hospital, Peradeniya, Sri Lanka. Pattern reversal visual evoked potentials, pattern electroretinography and electro-oculography were recorded in all of them. RESULTS: Twenty-four patients (64.9%) had reduced light peak:dark trough ratio values. The median light peak:dark trough ratio ± inter quartile range of the patient group (1.50 ± 0.4) was significantly lower than that of the controls (1.80 ± 0.2), (p < 0.001). Median dark trough value was significantly higher in patients compared to the control value. These changes may be due to higher conductance of ion channels in the retinal pigment epithelium, sub retinal space creation, changes in choroidal circulation or secondary to photoreceptor abnormalities in the macular region. These results indicate that retinal pigment epithelium might be affected in bilateral optic neuropathy.
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spelling pubmed-73105422020-06-24 Electro-oculography in bilateral optic neuropathy Dahanayake, Padmini Dassanayake, Tharaka L. Pathirage, Manoji Senanayake, Saman Sedgwick, Mike Weerasinghe, Vajira BMC Res Notes Research Note OBJECTIVE: Effect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light peak and dark trough values of electro-oculography. Thirty-seven patients with a clinical diagnosis of bilateral optic neuropathy and 40 control subjects were recruited in this observational, cross-sectional study, carried out at the Neurophysiology unit, Teaching Hospital, Peradeniya, Sri Lanka. Pattern reversal visual evoked potentials, pattern electroretinography and electro-oculography were recorded in all of them. RESULTS: Twenty-four patients (64.9%) had reduced light peak:dark trough ratio values. The median light peak:dark trough ratio ± inter quartile range of the patient group (1.50 ± 0.4) was significantly lower than that of the controls (1.80 ± 0.2), (p < 0.001). Median dark trough value was significantly higher in patients compared to the control value. These changes may be due to higher conductance of ion channels in the retinal pigment epithelium, sub retinal space creation, changes in choroidal circulation or secondary to photoreceptor abnormalities in the macular region. These results indicate that retinal pigment epithelium might be affected in bilateral optic neuropathy. BioMed Central 2020-06-12 /pmc/articles/PMC7310542/ /pubmed/32571391 http://dx.doi.org/10.1186/s13104-020-05131-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Dahanayake, Padmini
Dassanayake, Tharaka L.
Pathirage, Manoji
Senanayake, Saman
Sedgwick, Mike
Weerasinghe, Vajira
Electro-oculography in bilateral optic neuropathy
title Electro-oculography in bilateral optic neuropathy
title_full Electro-oculography in bilateral optic neuropathy
title_fullStr Electro-oculography in bilateral optic neuropathy
title_full_unstemmed Electro-oculography in bilateral optic neuropathy
title_short Electro-oculography in bilateral optic neuropathy
title_sort electro-oculography in bilateral optic neuropathy
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310542/
https://www.ncbi.nlm.nih.gov/pubmed/32571391
http://dx.doi.org/10.1186/s13104-020-05131-0
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