Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

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The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutralizing antibodies. Here we experimentally measure how all amino-acid mutations to the RBD affect expression of fo...

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Detalles Bibliográficos
Autores principales: Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Crawford, Katharine H.D., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., Veesler, David, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310626/
https://www.ncbi.nlm.nih.gov/pubmed/32587970
http://dx.doi.org/10.1101/2020.06.17.157982
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