Cargando…

The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

BACKGROUND: To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclea...

Descripción completa

Detalles Bibliográficos
Autores principales: Grant, Michael C., Geoghegan, Luke, Arbyn, Marc, Mohammed, Zakaria, McGuinness, Luke, Clarke, Emily L., Wade, Ryckie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310678/
https://www.ncbi.nlm.nih.gov/pubmed/32574165
http://dx.doi.org/10.1371/journal.pone.0234765
_version_ 1783549399648960512
author Grant, Michael C.
Geoghegan, Luke
Arbyn, Marc
Mohammed, Zakaria
McGuinness, Luke
Clarke, Emily L.
Wade, Ryckie G.
author_facet Grant, Michael C.
Geoghegan, Luke
Arbyn, Marc
Mohammed, Zakaria
McGuinness, Luke
Clarke, Emily L.
Wade, Ryckie G.
author_sort Grant, Michael C.
collection PubMed
description BACKGROUND: To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. METHODS: We searched PubMed, Embase, CINAHL, AMED, medRxiv and bioRxiv on 5(th) April 2020 for studies of adults (>16 years) with laboratory test confirmed COVID-19. No language or publication status restrictions were applied. Data were independently extracted by two review authors into standardised forms. All datapoints were independently checked by three other review authors. A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. I(2) was used to assess inter-study heterogeneity. RESULTS: Of 851 unique citations, 148 articles were included which comprised 24,410 adults with confirmed COVID-19 from 9 countries. The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I(2) 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I(2) 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I(2) 95%). Overall, 19% of hospitalised patients required non-invasive ventilation (44 studies, 6,513 patients), 17% required intensive care (33 studies, 7504 patients), 9% required invasive ventilation (45 studies, 6933 patients) and 2% required extra-corporeal membrane oxygenation (12 studies, 1,486 patients). The mortality rate was 7% (73 studies, 10,402 patients). CONCLUSIONS: We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. However, there is a large proportion of infected adults which symptoms-alone do not identify.
format Online
Article
Text
id pubmed-7310678
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-73106782020-06-25 The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries Grant, Michael C. Geoghegan, Luke Arbyn, Marc Mohammed, Zakaria McGuinness, Luke Clarke, Emily L. Wade, Ryckie G. PLoS One Research Article BACKGROUND: To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. METHODS: We searched PubMed, Embase, CINAHL, AMED, medRxiv and bioRxiv on 5(th) April 2020 for studies of adults (>16 years) with laboratory test confirmed COVID-19. No language or publication status restrictions were applied. Data were independently extracted by two review authors into standardised forms. All datapoints were independently checked by three other review authors. A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. I(2) was used to assess inter-study heterogeneity. RESULTS: Of 851 unique citations, 148 articles were included which comprised 24,410 adults with confirmed COVID-19 from 9 countries. The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I(2) 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I(2) 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I(2) 95%). Overall, 19% of hospitalised patients required non-invasive ventilation (44 studies, 6,513 patients), 17% required intensive care (33 studies, 7504 patients), 9% required invasive ventilation (45 studies, 6933 patients) and 2% required extra-corporeal membrane oxygenation (12 studies, 1,486 patients). The mortality rate was 7% (73 studies, 10,402 patients). CONCLUSIONS: We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. However, there is a large proportion of infected adults which symptoms-alone do not identify. Public Library of Science 2020-06-23 /pmc/articles/PMC7310678/ /pubmed/32574165 http://dx.doi.org/10.1371/journal.pone.0234765 Text en © 2020 Grant et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Grant, Michael C.
Geoghegan, Luke
Arbyn, Marc
Mohammed, Zakaria
McGuinness, Luke
Clarke, Emily L.
Wade, Ryckie G.
The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
title The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
title_full The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
title_fullStr The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
title_full_unstemmed The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
title_short The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
title_sort prevalence of symptoms in 24,410 adults infected by the novel coronavirus (sars-cov-2; covid-19): a systematic review and meta-analysis of 148 studies from 9 countries
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310678/
https://www.ncbi.nlm.nih.gov/pubmed/32574165
http://dx.doi.org/10.1371/journal.pone.0234765
work_keys_str_mv AT grantmichaelc theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT geogheganluke theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT arbynmarc theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT mohammedzakaria theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT mcguinnessluke theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT clarkeemilyl theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT waderyckieg theprevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT grantmichaelc prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT geogheganluke prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT arbynmarc prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT mohammedzakaria prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT mcguinnessluke prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT clarkeemilyl prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries
AT waderyckieg prevalenceofsymptomsin24410adultsinfectedbythenovelcoronavirussarscov2covid19asystematicreviewandmetaanalysisof148studiesfrom9countries