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Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington’s Disease

In the BACHD mouse model of Huntington’s disease (HD), deletion of the N17 domain of the Huntingtin gene (BACHDΔN17, Q97) has been reported to lead to nuclear accumulation of mHTT and exacerbation of motor deficits, neuroinflammation and striatal atrophy (Gu et al., 2015). Here we characterized the...

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Detalles Bibliográficos
Autores principales:	Goodliffe, Joseph, Rubakovic, Anastasia, Chang, Wayne, Pathak, Dhruba, Luebke, Jennifer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310706/ https://www.ncbi.nlm.nih.gov/pubmed/32574176 http://dx.doi.org/10.1371/journal.pone.0234394

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