Cargando…
Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
AIM: To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause. METHODS: Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and pl...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310708/ https://www.ncbi.nlm.nih.gov/pubmed/32574226 http://dx.doi.org/10.1371/journal.pone.0235174 |
_version_ | 1783549407160958976 |
---|---|
author | Abildgaard, Julie Tingstedt, Jeanette Zhao, Yanan Hartling, Hans Jakob Pedersen, Anette Tønnes Lindegaard, Birgitte Dam Nielsen, Susanne |
author_facet | Abildgaard, Julie Tingstedt, Jeanette Zhao, Yanan Hartling, Hans Jakob Pedersen, Anette Tønnes Lindegaard, Birgitte Dam Nielsen, Susanne |
author_sort | Abildgaard, Julie |
collection | PubMed |
description | AIM: To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause. METHODS: Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause. RESULTS: Postmenopausal women tended to have higher leukocyte counts (5.4 x10(9) vs. 4.9 x10(9) cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x10(9) vs. 1.6 x10(9) cells/l, p = 0.01) and monocytes (0.5 x10(9) vs. 0.4 x10(9) cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-α (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-α, IL-1β and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/μl, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets. CONCLUSIONS: Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings. |
format | Online Article Text |
id | pubmed-7310708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73107082020-06-26 Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women Abildgaard, Julie Tingstedt, Jeanette Zhao, Yanan Hartling, Hans Jakob Pedersen, Anette Tønnes Lindegaard, Birgitte Dam Nielsen, Susanne PLoS One Research Article AIM: To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause. METHODS: Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause. RESULTS: Postmenopausal women tended to have higher leukocyte counts (5.4 x10(9) vs. 4.9 x10(9) cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x10(9) vs. 1.6 x10(9) cells/l, p = 0.01) and monocytes (0.5 x10(9) vs. 0.4 x10(9) cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-α (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-α, IL-1β and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/μl, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets. CONCLUSIONS: Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings. Public Library of Science 2020-06-23 /pmc/articles/PMC7310708/ /pubmed/32574226 http://dx.doi.org/10.1371/journal.pone.0235174 Text en © 2020 Abildgaard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Abildgaard, Julie Tingstedt, Jeanette Zhao, Yanan Hartling, Hans Jakob Pedersen, Anette Tønnes Lindegaard, Birgitte Dam Nielsen, Susanne Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women |
title | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women |
title_full | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women |
title_fullStr | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women |
title_full_unstemmed | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women |
title_short | Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women |
title_sort | increased systemic inflammation and altered distribution of t-cell subsets in postmenopausal women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310708/ https://www.ncbi.nlm.nih.gov/pubmed/32574226 http://dx.doi.org/10.1371/journal.pone.0235174 |
work_keys_str_mv | AT abildgaardjulie increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen AT tingstedtjeanette increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen AT zhaoyanan increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen AT hartlinghansjakob increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen AT pedersenanettetønnes increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen AT lindegaardbirgitte increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen AT damnielsensusanne increasedsystemicinflammationandaltereddistributionoftcellsubsetsinpostmenopausalwomen |