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Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women

AIM: To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause. METHODS: Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and pl...

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Autores principales: Abildgaard, Julie, Tingstedt, Jeanette, Zhao, Yanan, Hartling, Hans Jakob, Pedersen, Anette Tønnes, Lindegaard, Birgitte, Dam Nielsen, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310708/
https://www.ncbi.nlm.nih.gov/pubmed/32574226
http://dx.doi.org/10.1371/journal.pone.0235174
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author Abildgaard, Julie
Tingstedt, Jeanette
Zhao, Yanan
Hartling, Hans Jakob
Pedersen, Anette Tønnes
Lindegaard, Birgitte
Dam Nielsen, Susanne
author_facet Abildgaard, Julie
Tingstedt, Jeanette
Zhao, Yanan
Hartling, Hans Jakob
Pedersen, Anette Tønnes
Lindegaard, Birgitte
Dam Nielsen, Susanne
author_sort Abildgaard, Julie
collection PubMed
description AIM: To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause. METHODS: Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause. RESULTS: Postmenopausal women tended to have higher leukocyte counts (5.4 x10(9) vs. 4.9 x10(9) cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x10(9) vs. 1.6 x10(9) cells/l, p = 0.01) and monocytes (0.5 x10(9) vs. 0.4 x10(9) cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-α (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-α, IL-1β and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/μl, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets. CONCLUSIONS: Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings.
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spelling pubmed-73107082020-06-26 Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women Abildgaard, Julie Tingstedt, Jeanette Zhao, Yanan Hartling, Hans Jakob Pedersen, Anette Tønnes Lindegaard, Birgitte Dam Nielsen, Susanne PLoS One Research Article AIM: To investigate markers of systemic inflammation in pre- and postmenopausal women and identify possible predictors of systemic inflammation with menopause. METHODS: Cross-sectional study of 69 healthy women between 45- and 60 years. Blood samples were collected to assess leukocyte subsets and plasma cytokines. MRI and DXA scans were performed to assess body composition. Through uni- and multivariate analyses, follicle-stimulating hormone (FSH), visceral fat mass and age were evaluated as predictors of systemic inflammation in relation to menopause. RESULTS: Postmenopausal women tended to have higher leukocyte counts (5.4 x10(9) vs. 4.9 x10(9) cells/l, p = 0.05) reflected in increased total lymphocytes (1.8 x10(9) vs. 1.6 x10(9) cells/l, p = 0.01) and monocytes (0.5 x10(9) vs. 0.4 x10(9) cells/l, p = 0.02), compared to premenopausal women. Increased visceral fat mass was a strong predictor of high leukocyte subsets. Postmenopausal women had higher plasma TNF-α (2.24 vs. 1.91 pg/ml, p = 0.01) and IL-6 (0.45 vs. 0.33 pg/ml, p = 0.004) compared to premenopausal women and high FSH was a significant predictor of increased plasma TNF-α, IL-1β and IL-6. Menopause was further associated with increased T-cells (1,336 vs. 1,128 cells/μl, p = 0.04) reflected in significantly higher counts of exhausted-, senescent-, and memory CD4+ T-cell subsets. CONCLUSIONS: Menopause is associated with increased systemic inflammation as well as exhausted- and senescent T-cells. We suggest, that both increased visceral fat mass and declining sex hormone levels might contribute to postmenopausal systemic inflammation and calls for further large-scale studies to confirm these findings. Public Library of Science 2020-06-23 /pmc/articles/PMC7310708/ /pubmed/32574226 http://dx.doi.org/10.1371/journal.pone.0235174 Text en © 2020 Abildgaard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abildgaard, Julie
Tingstedt, Jeanette
Zhao, Yanan
Hartling, Hans Jakob
Pedersen, Anette Tønnes
Lindegaard, Birgitte
Dam Nielsen, Susanne
Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
title Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
title_full Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
title_fullStr Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
title_full_unstemmed Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
title_short Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women
title_sort increased systemic inflammation and altered distribution of t-cell subsets in postmenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310708/
https://www.ncbi.nlm.nih.gov/pubmed/32574226
http://dx.doi.org/10.1371/journal.pone.0235174
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