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Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants

Inappropriate use of antibacterials is a major public health challenge as it can promote emergence of resistance, wastage of financial resources, morbidity and mortality. In this study, we determined the prevalence and factors associated with antibacterial use in managing symptoms of acute respirato...

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Autores principales: Lanyero, Hindum, Eriksen, Jaran, Obua, Celestino, Stålsby Lundborg, Cecilia, Nanzigu, Sarah, Katureebe, Agaba, Kalyango, Joan N., Ocan, Moses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310710/
https://www.ncbi.nlm.nih.gov/pubmed/32574206
http://dx.doi.org/10.1371/journal.pone.0235164
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author Lanyero, Hindum
Eriksen, Jaran
Obua, Celestino
Stålsby Lundborg, Cecilia
Nanzigu, Sarah
Katureebe, Agaba
Kalyango, Joan N.
Ocan, Moses
author_facet Lanyero, Hindum
Eriksen, Jaran
Obua, Celestino
Stålsby Lundborg, Cecilia
Nanzigu, Sarah
Katureebe, Agaba
Kalyango, Joan N.
Ocan, Moses
author_sort Lanyero, Hindum
collection PubMed
description Inappropriate use of antibacterials is a major public health challenge as it can promote emergence of resistance, wastage of financial resources, morbidity and mortality. In this study, we determined the prevalence and factors associated with antibacterial use in managing symptoms of acute respiratory tract infections (ARIs) in households in rural communities of Gulu district, northern Uganda. A cross-sectional study was conducted among households selected using multi-stage sampling. Data were collected through interviews with care-givers of children under five years, using a structured interviewer administered questionnaire. Out of the 856 children who had symptoms of ARIs, 515 (60.2%; CI: 54.5%-65.6%) were treated with antibacterials. The most commonly used antibacterials were amoxicillin (55.2%, n = 358), cotrimoxazole (15.4%, n = 100) and metronidazole (11.4%, n = 74). The determinants of antibacterial use included; getting treatment from a health facility (AOR: 1.85, CI: 1.34–2.56, P < 0.001), households located in peri-urban area (AOR: 2.54, CI: 1.34–4.84, P = 0.005), and a child having cough (AOR: 7.02, CI: 4.36–11.31, P < 0.001). The prevalence of antibacterial use among children under five years with symptoms of ARIs is high in communities of Gulu district, northern Uganda. Getting treatment from a health facility, if a household was located in a peri-urban area and having a cough are positive predictors of antibacterial use. There is need for targeted education on appropriate antibacterial use in rural communities and hospital settings where over prescription is most likely especially in treating symptoms of ARIs among children under five years.
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spelling pubmed-73107102020-06-26 Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants Lanyero, Hindum Eriksen, Jaran Obua, Celestino Stålsby Lundborg, Cecilia Nanzigu, Sarah Katureebe, Agaba Kalyango, Joan N. Ocan, Moses PLoS One Research Article Inappropriate use of antibacterials is a major public health challenge as it can promote emergence of resistance, wastage of financial resources, morbidity and mortality. In this study, we determined the prevalence and factors associated with antibacterial use in managing symptoms of acute respiratory tract infections (ARIs) in households in rural communities of Gulu district, northern Uganda. A cross-sectional study was conducted among households selected using multi-stage sampling. Data were collected through interviews with care-givers of children under five years, using a structured interviewer administered questionnaire. Out of the 856 children who had symptoms of ARIs, 515 (60.2%; CI: 54.5%-65.6%) were treated with antibacterials. The most commonly used antibacterials were amoxicillin (55.2%, n = 358), cotrimoxazole (15.4%, n = 100) and metronidazole (11.4%, n = 74). The determinants of antibacterial use included; getting treatment from a health facility (AOR: 1.85, CI: 1.34–2.56, P < 0.001), households located in peri-urban area (AOR: 2.54, CI: 1.34–4.84, P = 0.005), and a child having cough (AOR: 7.02, CI: 4.36–11.31, P < 0.001). The prevalence of antibacterial use among children under five years with symptoms of ARIs is high in communities of Gulu district, northern Uganda. Getting treatment from a health facility, if a household was located in a peri-urban area and having a cough are positive predictors of antibacterial use. There is need for targeted education on appropriate antibacterial use in rural communities and hospital settings where over prescription is most likely especially in treating symptoms of ARIs among children under five years. Public Library of Science 2020-06-23 /pmc/articles/PMC7310710/ /pubmed/32574206 http://dx.doi.org/10.1371/journal.pone.0235164 Text en © 2020 Lanyero et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lanyero, Hindum
Eriksen, Jaran
Obua, Celestino
Stålsby Lundborg, Cecilia
Nanzigu, Sarah
Katureebe, Agaba
Kalyango, Joan N.
Ocan, Moses
Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants
title Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants
title_full Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants
title_fullStr Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants
title_full_unstemmed Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants
title_short Use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in Gulu, northern Uganda: Prevalence and determinants
title_sort use of antibacterials in the management of symptoms of acute respiratory tract infections among children under five years in gulu, northern uganda: prevalence and determinants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310710/
https://www.ncbi.nlm.nih.gov/pubmed/32574206
http://dx.doi.org/10.1371/journal.pone.0235164
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