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Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day

Significance: Our study reveals that frontal cerebral oxygenation asymmetry (FCOA), i.e. a difference in the oxygenation between the right and left prefrontal cortex (PFC), is a real phenomenon in healthy human subjects at rest. Aim: To investigate FCOA, we performed a study with 134 healthy right-h...

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Autores principales: Zohdi, Hamoon, Scholkmann, Felix, Wolf, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310879/
https://www.ncbi.nlm.nih.gov/pubmed/32607390
http://dx.doi.org/10.1117/1.NPh.7.2.025006
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author Zohdi, Hamoon
Scholkmann, Felix
Wolf, Ursula
author_facet Zohdi, Hamoon
Scholkmann, Felix
Wolf, Ursula
author_sort Zohdi, Hamoon
collection PubMed
description Significance: Our study reveals that frontal cerebral oxygenation asymmetry (FCOA), i.e. a difference in the oxygenation between the right and left prefrontal cortex (PFC), is a real phenomenon in healthy human subjects at rest. Aim: To investigate FCOA, we performed a study with 134 healthy right-handed subjects with the systemic physiology augmented functional near infrared spectroscopy (SPA-fNIRS) approach. Approach: Subjects were measured 2 to 4 times on different days resulting in an unprecedented number of 518 single measurements of the absolute values of tissue oxygen saturation ([Formula: see text]) and total hemoglobin concentration ([tHb]) of the right and left PFC. Measurements were performed with frequency-domain functional near-infrared spectroscopy. In addition, the cardiorespiratory parameters were measured simultaneously. Results: We found that (i) subjects showed an FCOA (higher [Formula: see text] on the right PFC), but not for tHb; (ii) intrasubject variability was excellent for both [Formula: see text] and tHb, and fair for FCOA; (iii)  [Formula: see text] correlated significantly with blood [Formula: see text] concentration, [tHb] with heart rate, respiration rate (RR), and the pulse–respiration quotient (PRQ), and FCOA with RR and PRQ; (iv) FCOA and [Formula: see text] were dependent on season and time of day, respectively; (v) FCOA was negatively correlated with the room temperature; and (vi)  [Formula: see text] and tHb were not correlated with the subjects mood but with their chronotype, whereas FCOA was not dependent on the chronotype. Conclusion: Our study demonstrates that FCOA is real, and it provides unique insights into this remarkable phenomenon.
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spelling pubmed-73108792020-06-29 Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day Zohdi, Hamoon Scholkmann, Felix Wolf, Ursula Neurophotonics Research Papers Significance: Our study reveals that frontal cerebral oxygenation asymmetry (FCOA), i.e. a difference in the oxygenation between the right and left prefrontal cortex (PFC), is a real phenomenon in healthy human subjects at rest. Aim: To investigate FCOA, we performed a study with 134 healthy right-handed subjects with the systemic physiology augmented functional near infrared spectroscopy (SPA-fNIRS) approach. Approach: Subjects were measured 2 to 4 times on different days resulting in an unprecedented number of 518 single measurements of the absolute values of tissue oxygen saturation ([Formula: see text]) and total hemoglobin concentration ([tHb]) of the right and left PFC. Measurements were performed with frequency-domain functional near-infrared spectroscopy. In addition, the cardiorespiratory parameters were measured simultaneously. Results: We found that (i) subjects showed an FCOA (higher [Formula: see text] on the right PFC), but not for tHb; (ii) intrasubject variability was excellent for both [Formula: see text] and tHb, and fair for FCOA; (iii)  [Formula: see text] correlated significantly with blood [Formula: see text] concentration, [tHb] with heart rate, respiration rate (RR), and the pulse–respiration quotient (PRQ), and FCOA with RR and PRQ; (iv) FCOA and [Formula: see text] were dependent on season and time of day, respectively; (v) FCOA was negatively correlated with the room temperature; and (vi)  [Formula: see text] and tHb were not correlated with the subjects mood but with their chronotype, whereas FCOA was not dependent on the chronotype. Conclusion: Our study demonstrates that FCOA is real, and it provides unique insights into this remarkable phenomenon. Society of Photo-Optical Instrumentation Engineers 2020-06-23 2020-04 /pmc/articles/PMC7310879/ /pubmed/32607390 http://dx.doi.org/10.1117/1.NPh.7.2.025006 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/ Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Research Papers
Zohdi, Hamoon
Scholkmann, Felix
Wolf, Ursula
Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
title Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
title_full Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
title_fullStr Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
title_full_unstemmed Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
title_short Frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
title_sort frontal cerebral oxygenation asymmetry: intersubject variability and dependence on systemic physiology, season, and time of day
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310879/
https://www.ncbi.nlm.nih.gov/pubmed/32607390
http://dx.doi.org/10.1117/1.NPh.7.2.025006
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