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Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China

OBJECTIVES: To demonstrate the accuracy and flexibility of using waist-to-height ratio (WHtR) as a screening tool for identifying children and adolescents with cardiometabolic risk (CMR) across a wide range of prevalence levels among general paediatric populations. DESIGN: A nationwide population-ba...

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Autores principales: Dou, Yalan, Jiang, Yuan, Yan, Yinkun, Chen, Hongyan, Zhang, Yi, Chen, Xiaotian, Wang, Yin, Cheng, Hong, Zhao, Xiaoyuan, Hou, Dongqing, Mi, Jie, Yan, Weili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311015/
https://www.ncbi.nlm.nih.gov/pubmed/32565476
http://dx.doi.org/10.1136/bmjopen-2020-037040
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author Dou, Yalan
Jiang, Yuan
Yan, Yinkun
Chen, Hongyan
Zhang, Yi
Chen, Xiaotian
Wang, Yin
Cheng, Hong
Zhao, Xiaoyuan
Hou, Dongqing
Mi, Jie
Yan, Weili
author_facet Dou, Yalan
Jiang, Yuan
Yan, Yinkun
Chen, Hongyan
Zhang, Yi
Chen, Xiaotian
Wang, Yin
Cheng, Hong
Zhao, Xiaoyuan
Hou, Dongqing
Mi, Jie
Yan, Weili
author_sort Dou, Yalan
collection PubMed
description OBJECTIVES: To demonstrate the accuracy and flexibility of using waist-to-height ratio (WHtR) as a screening tool for identifying children and adolescents with cardiometabolic risk (CMR) across a wide range of prevalence levels among general paediatric populations. DESIGN: A nationwide population-based cross-sectional study with all data collected at school settings in six cities of China. PARTICIPANTS: A total of 8130 children and adolescents aged 7–18 years with complete anthropometric and CMR measurements based on blood tests were recruited. OUTCOME MEASURES: Elevated blood pressure, dyslipidaemia, elevated fasting blood glucose and central obesity were measured. The primary outcome, CMRs, was defined as meeting three or more of the above risk factors. The accuracy of WHtR for identifying CMRs was evaluated using areas under the curves (AUCs) with 95% CI of the receiver operating characteristic curve. The predictability of WHtR at given CMRs prevalence levels was estimated by positive predictive value (PPV) and negative predictive value. RESULTS: Overall, 6.1% of study participants were presented with CMRs. WHtR had high AUCs ranging from 0.84 (95% CI 0.81 to 0.88) to 0.88 (95% CI 0.86 to 0.90) in the total population and age-subgroup and gender-subgroup. The overall optimal WHtR cut-off value was 0.467, with boys having a higher cut-off than girls (0.481 vs 0.456). WHtR achieved an overall sensitivity of 0.89 and PPV of 18.8% at a specificity of 0.75. The screening performance of WHtR remained satisfactory across a wide range of given CMRs prevalence levels (5%, 10% and 20%). CONCLUSION: WHtR as a screening tool could accurately and flexibly identify children affected with the clusters of three or more of CMR factors from the general paediatric population with various CMR prevalence levels. Our findings provide support for policy-making on early CMR identification and management in the high-risk group of children.
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spelling pubmed-73110152020-06-26 Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China Dou, Yalan Jiang, Yuan Yan, Yinkun Chen, Hongyan Zhang, Yi Chen, Xiaotian Wang, Yin Cheng, Hong Zhao, Xiaoyuan Hou, Dongqing Mi, Jie Yan, Weili BMJ Open Public Health OBJECTIVES: To demonstrate the accuracy and flexibility of using waist-to-height ratio (WHtR) as a screening tool for identifying children and adolescents with cardiometabolic risk (CMR) across a wide range of prevalence levels among general paediatric populations. DESIGN: A nationwide population-based cross-sectional study with all data collected at school settings in six cities of China. PARTICIPANTS: A total of 8130 children and adolescents aged 7–18 years with complete anthropometric and CMR measurements based on blood tests were recruited. OUTCOME MEASURES: Elevated blood pressure, dyslipidaemia, elevated fasting blood glucose and central obesity were measured. The primary outcome, CMRs, was defined as meeting three or more of the above risk factors. The accuracy of WHtR for identifying CMRs was evaluated using areas under the curves (AUCs) with 95% CI of the receiver operating characteristic curve. The predictability of WHtR at given CMRs prevalence levels was estimated by positive predictive value (PPV) and negative predictive value. RESULTS: Overall, 6.1% of study participants were presented with CMRs. WHtR had high AUCs ranging from 0.84 (95% CI 0.81 to 0.88) to 0.88 (95% CI 0.86 to 0.90) in the total population and age-subgroup and gender-subgroup. The overall optimal WHtR cut-off value was 0.467, with boys having a higher cut-off than girls (0.481 vs 0.456). WHtR achieved an overall sensitivity of 0.89 and PPV of 18.8% at a specificity of 0.75. The screening performance of WHtR remained satisfactory across a wide range of given CMRs prevalence levels (5%, 10% and 20%). CONCLUSION: WHtR as a screening tool could accurately and flexibly identify children affected with the clusters of three or more of CMR factors from the general paediatric population with various CMR prevalence levels. Our findings provide support for policy-making on early CMR identification and management in the high-risk group of children. BMJ Publishing Group 2020-06-21 /pmc/articles/PMC7311015/ /pubmed/32565476 http://dx.doi.org/10.1136/bmjopen-2020-037040 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Public Health
Dou, Yalan
Jiang, Yuan
Yan, Yinkun
Chen, Hongyan
Zhang, Yi
Chen, Xiaotian
Wang, Yin
Cheng, Hong
Zhao, Xiaoyuan
Hou, Dongqing
Mi, Jie
Yan, Weili
Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China
title Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China
title_full Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China
title_fullStr Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China
title_full_unstemmed Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China
title_short Waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in China
title_sort waist-to-height ratio as a screening tool for cardiometabolic risk in children and adolescents: a nationwide cross-sectional study in china
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311015/
https://www.ncbi.nlm.nih.gov/pubmed/32565476
http://dx.doi.org/10.1136/bmjopen-2020-037040
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