Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Most therapeutic monoclonal antibodies in biopharmaceutical processes are produced in Chinese hamster ovary (CHO) cells. Technological advances have rendered the selection procedure for higher producers a robust protocol. However, information on molecular mechanisms that impart the property of hyper...

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Detalles Bibliográficos
Autores principales: Dahodwala, Hussain, Kaushik, Prashant, Tejwani, Vijay, Kuo, Chih-Chung, Menard, Patrice, Henry, Michael, Voldborg, Bjorn G., Lewis, Nathan E., Meleady, Paula, Sharfstein, Susan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311070/
https://www.ncbi.nlm.nih.gov/pubmed/32577618
http://dx.doi.org/10.1016/j.crbiot.2019.09.001

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