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Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells

Although mTORC1 negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signaling, in particular in vivo, is less clear. Here we show that autophagy supports mTORC1 hyperactivation in NSCs lacking Tsc1, thereby promoting defects in NSC maintenance, differentiation, tumourigene...

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Detalles Bibliográficos
Autores principales:	Wang, Chenran, Haas, Michael A., Yang, Fuchun, Yeo, Syn, Okamoto, Takako, Chen, Song, Wen, Jian, Sarma, Pranjal, Plas, David R., Guan, Jun-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311104/ https://www.ncbi.nlm.nih.gov/pubmed/32577608 http://dx.doi.org/10.1038/s42255-019-0137-5

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