Cargando…

Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care

BACKGROUND: Prescribing high doses of methotrexate increases the potentially fatal risk of toxicity. To minimise risk, it is recommended that only 2.5 mg tablets are used. AIM: To describe trends in GP prescribing of methotrexate over time; the harm associated with methotrexate errors at a national...

Descripción completa

Detalles Bibliográficos
Autores principales:	MacKenna, Brian, Curtis, Helen J, Walker, Alex J, Croker, Richard, Bacon, Seb, Goldacre, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal College of General Practitioners 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311108/ https://www.ncbi.nlm.nih.gov/pubmed/32571771 http://dx.doi.org/10.3399/bjgp20X710993

Ejemplares similares

Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care
por: MacKenna, Brian, et al.
Publicado: (2020)

Trends, geographical variation and factors associated with prescribing of gluten-free foods in English primary care: a cross-sectional study
por: Walker, Alex J, et al.
Publicado: (2018)

New mechanism to identify cost savings in English NHS prescribing: minimising ‘price per unit’, a cross-sectional study
por: Croker, Richard, et al.
Publicado: (2018)

Prescription of suboptimal statin treatment regimens: a retrospective cohort study of trends and variation in English primary care
por: Curtis, Helen J, et al.
Publicado: (2020)

Measuring the Impact of an Open Web-Based Prescribing Data Analysis Service on Clinical Practice: Cohort Study on NHS England Data
por: Walker, Alex J, et al.
Publicado: (2019)

Detecting change in comparison to peers in NHS prescribing data: a novel application of cumulative sum methodology
por: Walker, Alex J., et al.
Publicado: (2018)

OpenPrescribing: normalised data and software tool to research trends in English NHS primary care prescribing 1998–2016
por: Curtis, Helen J, et al.
Publicado: (2018)

Time trends and geographical variation in prescribing of drugs for diabetes in England from 1998 to 2017
por: Curtis, Helen J., et al.
Publicado: (2018)

Trends and variation in antidepressant prescribing in English primary care: a retrospective longitudinal study
por: Bogowicz, Paul, et al.
Publicado: (2021)

The clinician impact and financial cost to the NHS of litigation over pregabalin: a cohort study in English primary care
por: Croker, Richard, et al.
Publicado: (2018)

Identifying Patterns of Clinical Interest in Clinicians’ Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review
por: MacKenna, Brian, et al.
Publicado: (2022)

Variation in responsiveness to warranted behaviour change among NHS clinicians: novel implementation of change detection methods in longitudinal prescribing data
por: Walker, Alex J, et al.
Publicado: (2019)

Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
por: Hopcroft, Lisa EM, et al.
Publicado: (2023)

Do doctors in dispensing practices with a financial conflict of interest prescribe more expensive drugs? A cross-sectional analysis of English primary care prescribing data
por: Goldacre, Ben, et al.
Publicado: (2019)

Projected spending for brand-name drugs in English primary care given US prices: a cross-sectional study
por: Liu, Michael, et al.
Publicado: (2020)

OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19
por: Curtis, Helen J, et al.
Publicado: (2021)

Geographic Variation in Drug Safety: Potentially Unsafe Prescribing of Medications and Prescriber Responsiveness to Safety Alerts
por: Feifer, Richard A., et al.
Publicado: (2010)

Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP
por: Lemanska, Agnieszka, et al.
Publicado: (2023)

Examining variations in hospital productivity in the English NHS
por: Castelli, Adriana, et al.
Publicado: (2014)

Barriers to Working With National Health Service England’s Open Data
por: Bacon, Seb, et al.
Publicado: (2020)

A national audit of pancreatic enzyme prescribing in pancreatic cancer from 2015 to 2023 in England using OpenSAFELY-TPP
por: Lemanska, Agnieszka, et al.
Publicado: (2023)

The impact of COVID-19 on antibiotic prescribing in primary care in England: Evaluation and risk prediction of appropriateness of type and repeat prescribing
por: Zhong, Xiaomin, et al.
Publicado: (2023)

OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care clinical activity in England during the COVID-19 pandemic
por: Curtis, Helen J, et al.
Publicado: (2023)

Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform
por: Schultze, Anna, et al.
Publicado: (2020)

Impact of NICE guidance on tamoxifen prescribing in England 2011–2017: an interrupted time series analysis
por: Curtis, Helen J., et al.
Publicado: (2018)

A comprehensive high cost drugs dataset from the NHS in England - An OpenSAFELY-TPP Short Data Report
por: Rowan, Anna, et al.
Publicado: (2021)

Compliance with requirement to report results on the EU Clinical Trials Register: cohort study and web resource
por: Goldacre, Ben, et al.
Publicado: (2018)

The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England
por: Yang, Ya-Ting, et al.
Publicado: (2023)

Trends in and drivers of healthcare expenditure in the English NHS: a retrospective analysis
por: Rodriguez Santana, Idaira, et al.
Publicado: (2020)

The Use and Functionality of Electronic Prescribing Systems in English Acute NHS Trusts: A Cross-Sectional Survey
por: Ahmed, Zamzam, et al.
Publicado: (2013)

Hospital Trusts productivity in the English NHS: Uncovering possible drivers of productivity variations
por: Aragon Aragon, María Jose, et al.
Publicado: (2017)

Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY
por: Walker, Alex J, et al.
Publicado: (2021)

The "Unsafe" Ear
por: Birrell, J. F.
Publicado: (1945)

Reply to Comment on ‘Impact of NICE guidance on tamoxifen prescribing in England 2011–2017: an interrupted time series analysis”
por: Curtis, Helen, et al.
Publicado: (2018)

Sodium polystyrene is unsafe and should not be prescribed for the treatment of hyperkalaemia: primum non nocere!
por: Rossignol, Patrick, et al.
Publicado: (2023)

Private prescribing of controlled opioids in England, 2014–2021: a retrospective observational study
por: Martus, Isabella, et al.
Publicado: (2023)

Impact of COVID-19 on broad-spectrum antibiotic prescribing for common infections in primary care in England: a time-series analyses using OpenSAFELY and effects of predictors including deprivation
por: Zhong, Xiaomin, et al.
Publicado: (2023)

OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic
por: Curtis, Helen J, et al.
Publicado: (2021)

OpenSAFELY: factors associated with COVID-19 death in 17 million patients
por: Williamson, Elizabeth J, et al.
Publicado: (2020)

Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study
por: Wong, Angel YS, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_agoj66paucs51n13b7r7sg6goj