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Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

Class I PI3K enzymes are critical for the maintenance of effective immunity. In T cells, PI3Kα and PI3Kδ are activated by the TCR and costimulatory receptors, whereas PI3Kγ is activated by G protein–coupled chemokine receptors. PI3Kδ is a key regulator of regulatory T (Treg) cell function. PI3K isof...

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Detalles Bibliográficos
Autores principales:	Stark, Anne-Katrien, Davenport, Elizabeth C. M., Patton, Daniel T., Scudamore, Cheryl L., Vanhaesebroeck, Bart, Veldhoen, Marc, Garden, Oliver A., Okkenhaug, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2020
Materias:	Immune Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311201/ https://www.ncbi.nlm.nih.gov/pubmed/32414808 http://dx.doi.org/10.4049/jimmunol.2000043

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