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Observation of processive telomerase catalysis using high-resolution optical tweezers

Telomere maintenance by telomerase is essential for continuous proliferation of human cells and is vital for the survival of stem cells and 90% of cancer cells. To compensate for telomeric DNA lost during DNA replication, telomerase processively adds GGTTAG repeats to chromosome ends by copying the...

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Detalles Bibliográficos
Autores principales:	Patrick, Eric M., Slivka, Joseph, Payne, Bramyn, Comstock, Matthew J., Schmidt, Jens C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311264/ https://www.ncbi.nlm.nih.gov/pubmed/32066968 http://dx.doi.org/10.1038/s41589-020-0478-0

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