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Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study

We compared the prognostic value of nutritional or volumetric parameters measured by body composition in hospitalized patients on maintenance hemodialysis. We conducted a cohort study to assess the association of different parameters of body composition with all-cause mortality in inpatients admitte...

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Autores principales: Wu, Buyun, Yan, Chenyan, Zhang, Sufeng, Ge, Yifei, Xu, Xueqiang, Wang, Yajie, Xu, Lin, Zhang, Chengning, Huang, Zhimin, Ren, Haibin, Wu, Jingjing, Xing, Changying, Mao, Huijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311464/
https://www.ncbi.nlm.nih.gov/pubmed/32576950
http://dx.doi.org/10.1038/s41598-020-67019-0
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author Wu, Buyun
Yan, Chenyan
Zhang, Sufeng
Ge, Yifei
Xu, Xueqiang
Wang, Yajie
Xu, Lin
Zhang, Chengning
Huang, Zhimin
Ren, Haibin
Wu, Jingjing
Xing, Changying
Mao, Huijuan
author_facet Wu, Buyun
Yan, Chenyan
Zhang, Sufeng
Ge, Yifei
Xu, Xueqiang
Wang, Yajie
Xu, Lin
Zhang, Chengning
Huang, Zhimin
Ren, Haibin
Wu, Jingjing
Xing, Changying
Mao, Huijuan
author_sort Wu, Buyun
collection PubMed
description We compared the prognostic value of nutritional or volumetric parameters measured by body composition in hospitalized patients on maintenance hemodialysis. We conducted a cohort study to assess the association of different parameters of body composition with all-cause mortality in inpatients admitted to our nephrology department from January 2014 to December 2016. Of the 704 study patients, 160 (22.7%) died during a median follow-up of 33 months. In multivariate adjusted Cox models, higher ratio of extracellular water to body cell mass (ECW/BCM) (adjusted HR per 1-SD, 1.49; 95% CI, 1.19 to 1.85), lower lean tissue index (LTI) (adjusted HR per 1-SD, 0.70; 95% CI, 0.57 to 0.86) and lower body cell mass index (BCMI) (adjusted HR per 1-SD, 0.70; 95% CI, 0.58 to 0.85) were associated with a significantly greater risk of death. When these parameters were added to the fully adjusted model, BCMI performed best in improving the predictability for all-cause mortality (integrated discrimination improvement = 0.02, P = 0.04; net reclassification index = 0.11, P = 0.04). Among body composition indexes, ECW/BCM was the most relevant fluid volume indices to mortality and BCMI and LTI were the most relevant nutritional status indices to mortality in maintenance hemodialysis patients.
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spelling pubmed-73114642020-06-25 Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study Wu, Buyun Yan, Chenyan Zhang, Sufeng Ge, Yifei Xu, Xueqiang Wang, Yajie Xu, Lin Zhang, Chengning Huang, Zhimin Ren, Haibin Wu, Jingjing Xing, Changying Mao, Huijuan Sci Rep Article We compared the prognostic value of nutritional or volumetric parameters measured by body composition in hospitalized patients on maintenance hemodialysis. We conducted a cohort study to assess the association of different parameters of body composition with all-cause mortality in inpatients admitted to our nephrology department from January 2014 to December 2016. Of the 704 study patients, 160 (22.7%) died during a median follow-up of 33 months. In multivariate adjusted Cox models, higher ratio of extracellular water to body cell mass (ECW/BCM) (adjusted HR per 1-SD, 1.49; 95% CI, 1.19 to 1.85), lower lean tissue index (LTI) (adjusted HR per 1-SD, 0.70; 95% CI, 0.57 to 0.86) and lower body cell mass index (BCMI) (adjusted HR per 1-SD, 0.70; 95% CI, 0.58 to 0.85) were associated with a significantly greater risk of death. When these parameters were added to the fully adjusted model, BCMI performed best in improving the predictability for all-cause mortality (integrated discrimination improvement = 0.02, P = 0.04; net reclassification index = 0.11, P = 0.04). Among body composition indexes, ECW/BCM was the most relevant fluid volume indices to mortality and BCMI and LTI were the most relevant nutritional status indices to mortality in maintenance hemodialysis patients. Nature Publishing Group UK 2020-06-23 /pmc/articles/PMC7311464/ /pubmed/32576950 http://dx.doi.org/10.1038/s41598-020-67019-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wu, Buyun
Yan, Chenyan
Zhang, Sufeng
Ge, Yifei
Xu, Xueqiang
Wang, Yajie
Xu, Lin
Zhang, Chengning
Huang, Zhimin
Ren, Haibin
Wu, Jingjing
Xing, Changying
Mao, Huijuan
Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study
title Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study
title_full Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study
title_fullStr Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study
title_full_unstemmed Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study
title_short Comparative Performance of Body Composition Parameters in Prediction of Death in Hospitalized Patients on Maintenance Hemodialysis: A Cohort Study
title_sort comparative performance of body composition parameters in prediction of death in hospitalized patients on maintenance hemodialysis: a cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311464/
https://www.ncbi.nlm.nih.gov/pubmed/32576950
http://dx.doi.org/10.1038/s41598-020-67019-0
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