Short-term exposure to air pollution (PM(2.5)) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice

A previous study demonstrated that a high-fat diet (HFD), administered for one-three-days, induces hypothalamic inflammation before obesity’s established, and the long term affects leptin signaling/action due to inflammation. We investigate whether exposure to particulate matter of a diameter of ≤2....

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Detalles Bibliográficos
Autores principales: Campolim, Clara Machado, Weissmann, Lais, Ferreira, Clílton Kraüss de Oliveira, Zordão, Olivia Pizetta, Dornellas, Ana Paula Segantine, de Castro, Gisele, Zanotto, Tamires Marques, Boico, Vitor Ferreira, Quaresma, Paula Gabriele Fernandes, Lima, Raquel Patrícia Ataíde, Donato, Jose, Veras, Mariana Matera, Saldiva, Paulo Hilário Nascimento, Kim, Young-Bum, Prada, Patricia Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311527/
https://www.ncbi.nlm.nih.gov/pubmed/32576879
http://dx.doi.org/10.1038/s41598-020-67040-3

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