Cargando…

Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma

Presarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). The Japan integrated staging (JIS) score is a prognostic method that combines the Child–Turcotte–Pugh classification and the tumor-node-metastasis (TNM) staging for HCC. We investigated the relationship between pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Takada, Hitomi, Amemiya, Fumitake, Yasumura, Tomoki, Yoda, Hiroki, Okuwaki, Tetsuya, Imagawa, Naoto, Shimamura, Naruki, Tanaka, Keisuke, Kadokura, Makoto, Maekawa, Shinya, Enomoto, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311529/
https://www.ncbi.nlm.nih.gov/pubmed/32576956
http://dx.doi.org/10.1038/s41598-020-67147-7
_version_ 1783549559398465536
author Takada, Hitomi
Amemiya, Fumitake
Yasumura, Tomoki
Yoda, Hiroki
Okuwaki, Tetsuya
Imagawa, Naoto
Shimamura, Naruki
Tanaka, Keisuke
Kadokura, Makoto
Maekawa, Shinya
Enomoto, Nobuyuki
author_facet Takada, Hitomi
Amemiya, Fumitake
Yasumura, Tomoki
Yoda, Hiroki
Okuwaki, Tetsuya
Imagawa, Naoto
Shimamura, Naruki
Tanaka, Keisuke
Kadokura, Makoto
Maekawa, Shinya
Enomoto, Nobuyuki
author_sort Takada, Hitomi
collection PubMed
description Presarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). The Japan integrated staging (JIS) score is a prognostic method that combines the Child–Turcotte–Pugh classification and the tumor-node-metastasis (TNM) staging for HCC. We investigated the relationship between presarcopenia, the JIS score, and prognosis in patients with primary HCC. This retrospective study included 153 patients with primary HCC who were hospitalized from October 2011 to March 2018 at Municipal Hospital of Kofu. The skeletal muscle mass was measured using simplified psoas muscle mass index (PMI) based on CT imaging, and PMI using the volume analyzer SYNAPSE VINCENT ver3.0. We diagnosed presarcopenia based on the cut off value according to the assessment criteria for sarcopenia in liver disease defined by the Japan Society of Hepatology. Forty-three patients (28%) were diagnosed with presarcopenia. The median event-free survival was significantly worse in patients with presarcopenia than those without presarcopenia (P = 0.016). In multivariate analysis, presence of presarcopenia, JIS score ≥3, alpha-fetoprotein ≥200 ng/ml, and prothrombin induced by vitamin K absence-II ≥ 200 mAU/ml were significant prognostic factors. Among the patients with JIS scores ≥3, there was no difference in the event occurrence rate with presence of presarcopenia (P = 0.96). Among the patients with JIS scores ≤2, the median event-free-survival was significantly shorter in those with presarcopenia than those without presarcopenia (P = 0.045). Presarcopenia was an independent prognostic factor in patients with primary HCC. In patients with JIS scores ≤2, the median event-free survival was significantly shorter in those with presarcopenia compared to those without presarcopenia. In the patients with JIS scores ≥3, there was no difference in the event occurrence rates in those with and without presarcopenia.
format Online
Article
Text
id pubmed-7311529
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73115292020-06-25 Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma Takada, Hitomi Amemiya, Fumitake Yasumura, Tomoki Yoda, Hiroki Okuwaki, Tetsuya Imagawa, Naoto Shimamura, Naruki Tanaka, Keisuke Kadokura, Makoto Maekawa, Shinya Enomoto, Nobuyuki Sci Rep Article Presarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). The Japan integrated staging (JIS) score is a prognostic method that combines the Child–Turcotte–Pugh classification and the tumor-node-metastasis (TNM) staging for HCC. We investigated the relationship between presarcopenia, the JIS score, and prognosis in patients with primary HCC. This retrospective study included 153 patients with primary HCC who were hospitalized from October 2011 to March 2018 at Municipal Hospital of Kofu. The skeletal muscle mass was measured using simplified psoas muscle mass index (PMI) based on CT imaging, and PMI using the volume analyzer SYNAPSE VINCENT ver3.0. We diagnosed presarcopenia based on the cut off value according to the assessment criteria for sarcopenia in liver disease defined by the Japan Society of Hepatology. Forty-three patients (28%) were diagnosed with presarcopenia. The median event-free survival was significantly worse in patients with presarcopenia than those without presarcopenia (P = 0.016). In multivariate analysis, presence of presarcopenia, JIS score ≥3, alpha-fetoprotein ≥200 ng/ml, and prothrombin induced by vitamin K absence-II ≥ 200 mAU/ml were significant prognostic factors. Among the patients with JIS scores ≥3, there was no difference in the event occurrence rate with presence of presarcopenia (P = 0.96). Among the patients with JIS scores ≤2, the median event-free-survival was significantly shorter in those with presarcopenia than those without presarcopenia (P = 0.045). Presarcopenia was an independent prognostic factor in patients with primary HCC. In patients with JIS scores ≤2, the median event-free survival was significantly shorter in those with presarcopenia compared to those without presarcopenia. In the patients with JIS scores ≥3, there was no difference in the event occurrence rates in those with and without presarcopenia. Nature Publishing Group UK 2020-06-23 /pmc/articles/PMC7311529/ /pubmed/32576956 http://dx.doi.org/10.1038/s41598-020-67147-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Takada, Hitomi
Amemiya, Fumitake
Yasumura, Tomoki
Yoda, Hiroki
Okuwaki, Tetsuya
Imagawa, Naoto
Shimamura, Naruki
Tanaka, Keisuke
Kadokura, Makoto
Maekawa, Shinya
Enomoto, Nobuyuki
Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
title Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
title_full Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
title_fullStr Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
title_full_unstemmed Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
title_short Relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
title_sort relationship between presarcopenia and event occurrence in patients with primary hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311529/
https://www.ncbi.nlm.nih.gov/pubmed/32576956
http://dx.doi.org/10.1038/s41598-020-67147-7
work_keys_str_mv AT takadahitomi relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT amemiyafumitake relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT yasumuratomoki relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT yodahiroki relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT okuwakitetsuya relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT imagawanaoto relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT shimamuranaruki relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT tanakakeisuke relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT kadokuramakoto relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT maekawashinya relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma
AT enomotonobuyuki relationshipbetweenpresarcopeniaandeventoccurrenceinpatientswithprimaryhepatocellularcarcinoma