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NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection
We previously reported that NK cells can promote type 1 T cell immune response that is essential for protection to a primary infection of Chlamydia muridarum. In this study, we have investigated the contribution of NK cells to memory T cells associated immunity during chlamydial infection. We have f...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311576/ https://www.ncbi.nlm.nih.gov/pubmed/32626664 http://dx.doi.org/10.3389/fcimb.2020.00296 |
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author | Wang, Hong Li, Jing Dong, Xiaojing Zhou, Xaoqing Zhao, Lei Wang, Xiao Rashu, Rasheduzzaman Zhao, Weiming Yang, Xi |
author_facet | Wang, Hong Li, Jing Dong, Xiaojing Zhou, Xaoqing Zhao, Lei Wang, Xiao Rashu, Rasheduzzaman Zhao, Weiming Yang, Xi |
author_sort | Wang, Hong |
collection | PubMed |
description | We previously reported that NK cells can promote type 1 T cell immune response that is essential for protection to a primary infection of Chlamydia muridarum. In this study, we have investigated the contribution of NK cells to memory T cells associated immunity during chlamydial infection. We have found that NK cell depletion led to impaired production of IFN-γ by memory T cells upon re-stimulation with chlamydial antigens in vitro. Mice with depleted NK cells also exhibited reduced type 1 T cell recall responses, with increased production of IL-4 from CD4(+) T cells and a lower level of Chlamydia-specific IgG2a titers compared to control mice. In addition, Tregs response was significantly increased in mice with NK cell depletion. Moreover, NK cell-depleted mice showed an increased bacterial loads and more severe inflammatory pathological changes than control mice. These findings indicate that NK cells contribute to protective memory T cell associated immunity to chlamydial re-infection through modulating the cytokine pattern of T cell and inhibition of Tregs response. |
format | Online Article Text |
id | pubmed-7311576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73115762020-07-02 NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection Wang, Hong Li, Jing Dong, Xiaojing Zhou, Xaoqing Zhao, Lei Wang, Xiao Rashu, Rasheduzzaman Zhao, Weiming Yang, Xi Front Cell Infect Microbiol Cellular and Infection Microbiology We previously reported that NK cells can promote type 1 T cell immune response that is essential for protection to a primary infection of Chlamydia muridarum. In this study, we have investigated the contribution of NK cells to memory T cells associated immunity during chlamydial infection. We have found that NK cell depletion led to impaired production of IFN-γ by memory T cells upon re-stimulation with chlamydial antigens in vitro. Mice with depleted NK cells also exhibited reduced type 1 T cell recall responses, with increased production of IL-4 from CD4(+) T cells and a lower level of Chlamydia-specific IgG2a titers compared to control mice. In addition, Tregs response was significantly increased in mice with NK cell depletion. Moreover, NK cell-depleted mice showed an increased bacterial loads and more severe inflammatory pathological changes than control mice. These findings indicate that NK cells contribute to protective memory T cell associated immunity to chlamydial re-infection through modulating the cytokine pattern of T cell and inhibition of Tregs response. Frontiers Media S.A. 2020-06-17 /pmc/articles/PMC7311576/ /pubmed/32626664 http://dx.doi.org/10.3389/fcimb.2020.00296 Text en Copyright © 2020 Wang, Li, Dong, Zhou, Zhao, Wang, Rashu, Zhao and Yang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Wang, Hong Li, Jing Dong, Xiaojing Zhou, Xaoqing Zhao, Lei Wang, Xiao Rashu, Rasheduzzaman Zhao, Weiming Yang, Xi NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection |
title | NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection |
title_full | NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection |
title_fullStr | NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection |
title_full_unstemmed | NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection |
title_short | NK Cells Contribute to Protective Memory T Cell Mediated Immunity to Chlamydia muridarum Infection |
title_sort | nk cells contribute to protective memory t cell mediated immunity to chlamydia muridarum infection |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311576/ https://www.ncbi.nlm.nih.gov/pubmed/32626664 http://dx.doi.org/10.3389/fcimb.2020.00296 |
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