In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao-Jing, Qin, Juan-Juan, Cheng, Xu, Shen, Lijun, Zhao, Yan-Ci, Yuan, Yufeng, Lei, Fang, Chen, Ming-Ming, Yang, Huilin, Bai, Liangjie, Song, Xiaohui, Lin, Lijin, Xia, Meng, Zhou, Feng, Zhou, Jianghua, She, Zhi-Gang, Zhu, Lihua, Ma, Xinliang, Xu, Qingbo, Ye, Ping, Chen, Guohua, Liu, Liming, Mao, Weiming, Yan, Youqin, Xiao, Bing, Lu, Zhigang, Peng, Gang, Liu, Mingyu, Yang, Jun, Yang, Luyu, Zhang, Changjiang, Lu, Haofeng, Xia, Xigang, Wang, Daihong, Liao, Xiaofeng, Wei, Xiang, Zhang, Bing-Hong, Zhang, Xin, Yang, Juan, Zhao, Guang-Nian, Zhang, Peng, Liu, Peter P., Loomba, Rohit, Ji, Yan-Xiao, Xia, Jiahong, Wang, Yibin, Cai, Jingjing, Guo, Jiao, Li, Hongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311917/
https://www.ncbi.nlm.nih.gov/pubmed/32592657
http://dx.doi.org/10.1016/j.cmet.2020.06.015
Descripción
Sumario:Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.

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