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Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers
The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. Dysregulation of Wnt signaling is associated with various diseases such as cance...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311976/ https://www.ncbi.nlm.nih.gov/pubmed/32486158 http://dx.doi.org/10.3390/ijms21113904 |
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author | Park, Hong-Beom Kim, Ju-Won Baek, Kwang-Hyun |
author_facet | Park, Hong-Beom Kim, Ju-Won Baek, Kwang-Hyun |
author_sort | Park, Hong-Beom |
collection | PubMed |
description | The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. Dysregulation of Wnt signaling is associated with various diseases such as cancer, aging, Alzheimer’s disease, metabolic disease, and pigmentation disorders. Numerous studies entailing the Wnt signaling pathway have been conducted for various cancers. Diverse signaling factors mediate the up- or down-regulation of Wnt signaling through post-translational modifications (PTMs), and aberrant regulation is associated with several different malignancies in humans. Of the numerous PTMs involved, most Wnt signaling factors are regulated by ubiquitination and deubiquitination. Ubiquitination by E3 ligase attaches ubiquitins to target proteins and usually induces proteasomal degradation of Wnt signaling factors such as β-catenin, Axin, GSK3, and Dvl. Conversely, deubiquitination induced by the deubiquitinating enzymes (DUBs) detaches the ubiquitins and modulates the stability of signaling factors. In this review, we discuss the effects of ubiquitination and deubiquitination on the Wnt signaling pathway, and the inhibitors of DUBs that can be applied for cancer therapeutic strategies. |
format | Online Article Text |
id | pubmed-7311976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73119762020-06-25 Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers Park, Hong-Beom Kim, Ju-Won Baek, Kwang-Hyun Int J Mol Sci Review The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. Dysregulation of Wnt signaling is associated with various diseases such as cancer, aging, Alzheimer’s disease, metabolic disease, and pigmentation disorders. Numerous studies entailing the Wnt signaling pathway have been conducted for various cancers. Diverse signaling factors mediate the up- or down-regulation of Wnt signaling through post-translational modifications (PTMs), and aberrant regulation is associated with several different malignancies in humans. Of the numerous PTMs involved, most Wnt signaling factors are regulated by ubiquitination and deubiquitination. Ubiquitination by E3 ligase attaches ubiquitins to target proteins and usually induces proteasomal degradation of Wnt signaling factors such as β-catenin, Axin, GSK3, and Dvl. Conversely, deubiquitination induced by the deubiquitinating enzymes (DUBs) detaches the ubiquitins and modulates the stability of signaling factors. In this review, we discuss the effects of ubiquitination and deubiquitination on the Wnt signaling pathway, and the inhibitors of DUBs that can be applied for cancer therapeutic strategies. MDPI 2020-05-30 /pmc/articles/PMC7311976/ /pubmed/32486158 http://dx.doi.org/10.3390/ijms21113904 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Hong-Beom Kim, Ju-Won Baek, Kwang-Hyun Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers |
title | Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers |
title_full | Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers |
title_fullStr | Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers |
title_full_unstemmed | Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers |
title_short | Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers |
title_sort | regulation of wnt signaling through ubiquitination and deubiquitination in cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311976/ https://www.ncbi.nlm.nih.gov/pubmed/32486158 http://dx.doi.org/10.3390/ijms21113904 |
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