A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice

The N-methyl-(2S,4R)-trans-4-hydroxy-l-proline-enriched fraction (NMP) from Sideroxylon obtusifolium was evaluated as a neuroprotective agent in the intracerebroventricular (icv) pilocarpine (Pilo) model. To this aim, male mice were subdivided into sham (SO, vehicle), Pilo (300 µg/1 µL icv, followed...

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Detalles Bibliográficos
Autores principales: de Aquino, Pedro Everson Alexandre, Rabelo Bezerra, Jéssica, de Souza Nascimento, Tyciane, Tavares, Juliete, Rosal Lustosa, Ítalo, Chaves Filho, Adriano José Maia, Mottin, Melina, Macêdo Gaspar, Danielle, de Andrade, Geanne Matos, Tavares Neves, Kelly Rose, Biagini, Giuseppe, Silveira, Edilberto Rocha, de Barros Viana, Glauce Socorro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312019/
https://www.ncbi.nlm.nih.gov/pubmed/32545390
http://dx.doi.org/10.3390/ijms21114188

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