Cargando…
Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause approximately 2 million deaths per year worldwide and hepatic inflammation is a common factor to all of them, being t...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312021/ https://www.ncbi.nlm.nih.gov/pubmed/32485811 http://dx.doi.org/10.3390/ijms21113858 |
_version_ | 1783549638062637056 |
---|---|
author | de Gregorio, Estefanía Colell, Anna Morales, Albert Marí, Montserrat |
author_facet | de Gregorio, Estefanía Colell, Anna Morales, Albert Marí, Montserrat |
author_sort | de Gregorio, Estefanía |
collection | PubMed |
description | Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause approximately 2 million deaths per year worldwide and hepatic inflammation is a common factor to all of them, being the main driver of hepatic tissue damage and causing progression from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), cirrhosis and, ultimately, hepatocellular carcinoma (HCC). The metabolic sensor SIRT1, a class III histone deacetylase with strong expression in metabolic tissues such as the liver, and transcription factor NF-κB, a master regulator of inflammatory response, show an antagonistic relationship in controlling inflammation. For this reason, SIRT1 targeting is emerging as a potential strategy to improve different metabolic and/or inflammatory pathologies. In this review, we explore diverse upstream regulators and some natural/synthetic activators of SIRT1 as possible therapeutic treatment for liver diseases. |
format | Online Article Text |
id | pubmed-7312021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73120212020-06-25 Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease de Gregorio, Estefanía Colell, Anna Morales, Albert Marí, Montserrat Int J Mol Sci Review Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause approximately 2 million deaths per year worldwide and hepatic inflammation is a common factor to all of them, being the main driver of hepatic tissue damage and causing progression from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), cirrhosis and, ultimately, hepatocellular carcinoma (HCC). The metabolic sensor SIRT1, a class III histone deacetylase with strong expression in metabolic tissues such as the liver, and transcription factor NF-κB, a master regulator of inflammatory response, show an antagonistic relationship in controlling inflammation. For this reason, SIRT1 targeting is emerging as a potential strategy to improve different metabolic and/or inflammatory pathologies. In this review, we explore diverse upstream regulators and some natural/synthetic activators of SIRT1 as possible therapeutic treatment for liver diseases. MDPI 2020-05-29 /pmc/articles/PMC7312021/ /pubmed/32485811 http://dx.doi.org/10.3390/ijms21113858 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Gregorio, Estefanía Colell, Anna Morales, Albert Marí, Montserrat Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease |
title | Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease |
title_full | Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease |
title_fullStr | Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease |
title_full_unstemmed | Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease |
title_short | Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease |
title_sort | relevance of sirt1-nf-κb axis as therapeutic target to ameliorate inflammation in liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312021/ https://www.ncbi.nlm.nih.gov/pubmed/32485811 http://dx.doi.org/10.3390/ijms21113858 |
work_keys_str_mv | AT degregorioestefania relevanceofsirt1nfkbaxisastherapeutictargettoameliorateinflammationinliverdisease AT colellanna relevanceofsirt1nfkbaxisastherapeutictargettoameliorateinflammationinliverdisease AT moralesalbert relevanceofsirt1nfkbaxisastherapeutictargettoameliorateinflammationinliverdisease AT marimontserrat relevanceofsirt1nfkbaxisastherapeutictargettoameliorateinflammationinliverdisease |