Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-Induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model

We have shown that a high fat diet (HFD) induces the activation of retinal NOD-like receptor protein (NLRP3)-inflammasome that is associated with enhanced expression and interaction with thioredoxin-interacting protein (TXNIP). Here, the specific contribution of TXNIP and the impact of HFD on retina...

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Detalles Bibliográficos
Autores principales: Mohamed, Islam N., Sheibani, Nader, El-Remessy, Azza B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312035/
https://www.ncbi.nlm.nih.gov/pubmed/32492941
http://dx.doi.org/10.3390/ijms21113983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312035/
https://www.ncbi.nlm.nih.gov/pubmed/32492941
http://dx.doi.org/10.3390/ijms21113983

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