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Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action

Genetic up-regulation of mitochondrial 2-oxoglutarate dehydrogenase is known to increase reactive oxygen species, being detrimental for cancer cells. Thiamine diphosphate (ThDP, cocarboxylase) is an essential activator of the enzyme and inhibits p53–DNA binding in cancer cells. We hypothesize that t...

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Detalles Bibliográficos
Autores principales:	Bunik, Victoria I., Aleshin, Vasily A., Zhou, Xiaoshan, Tabakov, Vyacheslav Yu., Karlsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312097/ https://www.ncbi.nlm.nih.gov/pubmed/32466567 http://dx.doi.org/10.3390/ijms21113759

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