COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to e...

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Detalles Bibliográficos
Autor principal: Marchetti, Monia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312112/
https://www.ncbi.nlm.nih.gov/pubmed/32583086
http://dx.doi.org/10.1007/s00277-020-04138-8
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author Marchetti, Monia
author_facet Marchetti, Monia
author_sort Marchetti, Monia
collection PubMed
description COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials.
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spelling pubmed-73121122020-06-24 COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure Marchetti, Monia Ann Hematol Review Article COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials. Springer Berlin Heidelberg 2020-06-24 2020 /pmc/articles/PMC7312112/ /pubmed/32583086 http://dx.doi.org/10.1007/s00277-020-04138-8 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Marchetti, Monia
COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
title COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
title_full COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
title_fullStr COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
title_full_unstemmed COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
title_short COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
title_sort covid-19-driven endothelial damage: complement, hif-1, and abl2 are potential pathways of damage and targets for cure
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312112/
https://www.ncbi.nlm.nih.gov/pubmed/32583086
http://dx.doi.org/10.1007/s00277-020-04138-8
work_keys_str_mv AT marchettimonia covid19drivenendothelialdamagecomplementhif1andabl2arepotentialpathwaysofdamageandtargetsforcure

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