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Influence of gut microbiome on multiple myeloma: friend or foe?

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, which typically evolves over time from its precursor, monoclonal gammopathy of undetermined significance. While the underlying mechanisms of this evolution remain elusive, immunomodulatory factors affecting the bone mar...

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Autores principales: Ahmed, Nausheen, Ghannoum, Mahmoud, Gallogly, Molly, de Lima, Marcos, Malek, Ehsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312329/
https://www.ncbi.nlm.nih.gov/pubmed/32581045
http://dx.doi.org/10.1136/jitc-2020-000576
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author Ahmed, Nausheen
Ghannoum, Mahmoud
Gallogly, Molly
de Lima, Marcos
Malek, Ehsan
author_facet Ahmed, Nausheen
Ghannoum, Mahmoud
Gallogly, Molly
de Lima, Marcos
Malek, Ehsan
author_sort Ahmed, Nausheen
collection PubMed
description Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, which typically evolves over time from its precursor, monoclonal gammopathy of undetermined significance. While the underlying mechanisms of this evolution remain elusive, immunomodulatory factors affecting the bone marrow (BM) microenvironment are suspected to play a role. There is an increasing evidence that the gut microbiome exerts an influence on its host’s adaptive and innate immune systems, inflammatory pathways and the BM microenvironment. Dysbiosis, therefore, may impact tumorigenesis in MM. This article gives an overview of potential mechanisms by which the microbiome may influence the pathogenesis of MM, MM patients’ responses to treatment and toxicities experienced by MM patients undergoing autologous transplant. It also discusses the potential role of the mycobiome in MM, a less studied component of the microbiome.
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spelling pubmed-73123292020-06-26 Influence of gut microbiome on multiple myeloma: friend or foe? Ahmed, Nausheen Ghannoum, Mahmoud Gallogly, Molly de Lima, Marcos Malek, Ehsan J Immunother Cancer Commentary Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, which typically evolves over time from its precursor, monoclonal gammopathy of undetermined significance. While the underlying mechanisms of this evolution remain elusive, immunomodulatory factors affecting the bone marrow (BM) microenvironment are suspected to play a role. There is an increasing evidence that the gut microbiome exerts an influence on its host’s adaptive and innate immune systems, inflammatory pathways and the BM microenvironment. Dysbiosis, therefore, may impact tumorigenesis in MM. This article gives an overview of potential mechanisms by which the microbiome may influence the pathogenesis of MM, MM patients’ responses to treatment and toxicities experienced by MM patients undergoing autologous transplant. It also discusses the potential role of the mycobiome in MM, a less studied component of the microbiome. BMJ Publishing Group 2020-06-23 /pmc/articles/PMC7312329/ /pubmed/32581045 http://dx.doi.org/10.1136/jitc-2020-000576 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Commentary
Ahmed, Nausheen
Ghannoum, Mahmoud
Gallogly, Molly
de Lima, Marcos
Malek, Ehsan
Influence of gut microbiome on multiple myeloma: friend or foe?
title Influence of gut microbiome on multiple myeloma: friend or foe?
title_full Influence of gut microbiome on multiple myeloma: friend or foe?
title_fullStr Influence of gut microbiome on multiple myeloma: friend or foe?
title_full_unstemmed Influence of gut microbiome on multiple myeloma: friend or foe?
title_short Influence of gut microbiome on multiple myeloma: friend or foe?
title_sort influence of gut microbiome on multiple myeloma: friend or foe?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312329/
https://www.ncbi.nlm.nih.gov/pubmed/32581045
http://dx.doi.org/10.1136/jitc-2020-000576
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