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Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation

Inflammation is often equated to the physiological response to injury or infection. Inflammatory responses defined by cytokine storms control cellular mechanisms that can either resolve quickly (i.e., acute inflammation) or remain prolonged and unabated (i.e., chronic inflammation). Perhaps less wel...

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Autores principales: St-Germain, Lauren E., Castellana, Barbara, Baltayeva, Jennet, Beristain, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312391/
https://www.ncbi.nlm.nih.gov/pubmed/32471078
http://dx.doi.org/10.3390/ijms21113776
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author St-Germain, Lauren E.
Castellana, Barbara
Baltayeva, Jennet
Beristain, Alexander G.
author_facet St-Germain, Lauren E.
Castellana, Barbara
Baltayeva, Jennet
Beristain, Alexander G.
author_sort St-Germain, Lauren E.
collection PubMed
description Inflammation is often equated to the physiological response to injury or infection. Inflammatory responses defined by cytokine storms control cellular mechanisms that can either resolve quickly (i.e., acute inflammation) or remain prolonged and unabated (i.e., chronic inflammation). Perhaps less well-appreciated is the importance of inflammatory processes central to healthy pregnancy, including implantation, early stages of placentation, and parturition. Pregnancy juxtaposed with disease can lead to the perpetuation of aberrant inflammation that likely contributes to or potentiates maternal morbidity and poor fetal outcome. Maternal obesity, a prevalent condition within women of reproductive age, associates with increased risk of developing multiple pregnancy disorders. Importantly, chronic low-grade inflammation is thought to underlie the development of obesity-related obstetric and perinatal complications. While diverse subsets of uterine immune cells play central roles in initiating and maintaining healthy pregnancy, uterine leukocyte dysfunction as a result of maternal obesity may underpin the development of pregnancy disorders. In this review we discuss the current knowledge related to the impact of maternal obesity and obesity-associated inflammation on uterine immune cell function, utero-placental establishment, and pregnancy health.
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spelling pubmed-73123912020-06-26 Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation St-Germain, Lauren E. Castellana, Barbara Baltayeva, Jennet Beristain, Alexander G. Int J Mol Sci Review Inflammation is often equated to the physiological response to injury or infection. Inflammatory responses defined by cytokine storms control cellular mechanisms that can either resolve quickly (i.e., acute inflammation) or remain prolonged and unabated (i.e., chronic inflammation). Perhaps less well-appreciated is the importance of inflammatory processes central to healthy pregnancy, including implantation, early stages of placentation, and parturition. Pregnancy juxtaposed with disease can lead to the perpetuation of aberrant inflammation that likely contributes to or potentiates maternal morbidity and poor fetal outcome. Maternal obesity, a prevalent condition within women of reproductive age, associates with increased risk of developing multiple pregnancy disorders. Importantly, chronic low-grade inflammation is thought to underlie the development of obesity-related obstetric and perinatal complications. While diverse subsets of uterine immune cells play central roles in initiating and maintaining healthy pregnancy, uterine leukocyte dysfunction as a result of maternal obesity may underpin the development of pregnancy disorders. In this review we discuss the current knowledge related to the impact of maternal obesity and obesity-associated inflammation on uterine immune cell function, utero-placental establishment, and pregnancy health. MDPI 2020-05-27 /pmc/articles/PMC7312391/ /pubmed/32471078 http://dx.doi.org/10.3390/ijms21113776 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
St-Germain, Lauren E.
Castellana, Barbara
Baltayeva, Jennet
Beristain, Alexander G.
Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
title Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
title_full Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
title_fullStr Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
title_full_unstemmed Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
title_short Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
title_sort maternal obesity and the uterine immune cell landscape: the shaping role of inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312391/
https://www.ncbi.nlm.nih.gov/pubmed/32471078
http://dx.doi.org/10.3390/ijms21113776
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