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Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review
The global epidemic of Zika virus has been a major public health problem affecting pregnant women and their infants. Zika virus causes a viral disease transmitted to humans mainly by the infected Aedes mosquito bite. The infection is not severe in most cases; however, there is evidence that infectio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312578/ https://www.ncbi.nlm.nih.gov/pubmed/32471131 http://dx.doi.org/10.3390/ijerph17113806 |
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author | Antoniou, Evangelia Orovou, Eirini Sarella, Angeliki Iliadou, Maria Rigas, Nikolaos Palaska, Ermioni Iatrakis, Georgios Dagla, Maria |
author_facet | Antoniou, Evangelia Orovou, Eirini Sarella, Angeliki Iliadou, Maria Rigas, Nikolaos Palaska, Ermioni Iatrakis, Georgios Dagla, Maria |
author_sort | Antoniou, Evangelia |
collection | PubMed |
description | The global epidemic of Zika virus has been a major public health problem affecting pregnant women and their infants. Zika virus causes a viral disease transmitted to humans mainly by the infected Aedes mosquito bite. The infection is not severe in most cases; however, there is evidence that infection during pregnancy may be associated with fetal genetic abnormalities (including microcephaly). In addition to microcephaly and other malformations, some specific lesions in the central nervous system have been reported. The aim of this systematic review was to determine the risk of developing microcephaly in infants whose mothers were infected with Zika virus in pregnancy. Epidemiological studies and case reports were incorporated in our review, finally including 15 articles from an initial pool of 355 related papers. Most studies have linked maternal infection during pregnancy to the development of neonatal microcephaly. The period considered most dangerous is the first trimester and the beginning or the whole of the second trimester. In order to understand the relationship between Zika virus and microcephaly in infants, a cohort study will be able to estimate the time from the onset of Zika infection and the full spectrum of adverse pregnancy outcomes. |
format | Online Article Text |
id | pubmed-7312578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73125782020-06-29 Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review Antoniou, Evangelia Orovou, Eirini Sarella, Angeliki Iliadou, Maria Rigas, Nikolaos Palaska, Ermioni Iatrakis, Georgios Dagla, Maria Int J Environ Res Public Health Review The global epidemic of Zika virus has been a major public health problem affecting pregnant women and their infants. Zika virus causes a viral disease transmitted to humans mainly by the infected Aedes mosquito bite. The infection is not severe in most cases; however, there is evidence that infection during pregnancy may be associated with fetal genetic abnormalities (including microcephaly). In addition to microcephaly and other malformations, some specific lesions in the central nervous system have been reported. The aim of this systematic review was to determine the risk of developing microcephaly in infants whose mothers were infected with Zika virus in pregnancy. Epidemiological studies and case reports were incorporated in our review, finally including 15 articles from an initial pool of 355 related papers. Most studies have linked maternal infection during pregnancy to the development of neonatal microcephaly. The period considered most dangerous is the first trimester and the beginning or the whole of the second trimester. In order to understand the relationship between Zika virus and microcephaly in infants, a cohort study will be able to estimate the time from the onset of Zika infection and the full spectrum of adverse pregnancy outcomes. MDPI 2020-05-27 2020-06 /pmc/articles/PMC7312578/ /pubmed/32471131 http://dx.doi.org/10.3390/ijerph17113806 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Antoniou, Evangelia Orovou, Eirini Sarella, Angeliki Iliadou, Maria Rigas, Nikolaos Palaska, Ermioni Iatrakis, Georgios Dagla, Maria Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review |
title | Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review |
title_full | Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review |
title_fullStr | Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review |
title_full_unstemmed | Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review |
title_short | Zika Virus and the Risk of Developing Microcephaly in Infants: A Systematic Review |
title_sort | zika virus and the risk of developing microcephaly in infants: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312578/ https://www.ncbi.nlm.nih.gov/pubmed/32471131 http://dx.doi.org/10.3390/ijerph17113806 |
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