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The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312580/ https://www.ncbi.nlm.nih.gov/pubmed/32486295 http://dx.doi.org/10.3390/ijms21113935 |
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author | Rastädter, Kerstin Wurm, David J. Spadiut, Oliver Quehenberger, Julian |
author_facet | Rastädter, Kerstin Wurm, David J. Spadiut, Oliver Quehenberger, Julian |
author_sort | Rastädter, Kerstin |
collection | PubMed |
description | The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. The main biotechnological application of the membrane lipids of Sulfolobus spp. are so called archaeosomes. Archaeosomes are liposomes which are fully or partly generated from archaeal lipids and harbor the potential to be used as drug delivery systems for vaccines, proteins, peptides and nucleic acids. This review summarizes the influence of environmental parameters on the cell membrane of Sulfolobus spp. and the biotechnological applications of their membrane lipids. |
format | Online Article Text |
id | pubmed-7312580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73125802020-06-29 The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications Rastädter, Kerstin Wurm, David J. Spadiut, Oliver Quehenberger, Julian Int J Mol Sci Review The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. The main biotechnological application of the membrane lipids of Sulfolobus spp. are so called archaeosomes. Archaeosomes are liposomes which are fully or partly generated from archaeal lipids and harbor the potential to be used as drug delivery systems for vaccines, proteins, peptides and nucleic acids. This review summarizes the influence of environmental parameters on the cell membrane of Sulfolobus spp. and the biotechnological applications of their membrane lipids. MDPI 2020-05-30 /pmc/articles/PMC7312580/ /pubmed/32486295 http://dx.doi.org/10.3390/ijms21113935 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rastädter, Kerstin Wurm, David J. Spadiut, Oliver Quehenberger, Julian The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications |
title | The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications |
title_full | The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications |
title_fullStr | The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications |
title_full_unstemmed | The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications |
title_short | The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications |
title_sort | cell membrane of sulfolobus spp.—homeoviscous adaption and biotechnological applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312580/ https://www.ncbi.nlm.nih.gov/pubmed/32486295 http://dx.doi.org/10.3390/ijms21113935 |
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