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The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications

The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea,...

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Autores principales: Rastädter, Kerstin, Wurm, David J., Spadiut, Oliver, Quehenberger, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312580/
https://www.ncbi.nlm.nih.gov/pubmed/32486295
http://dx.doi.org/10.3390/ijms21113935
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author Rastädter, Kerstin
Wurm, David J.
Spadiut, Oliver
Quehenberger, Julian
author_facet Rastädter, Kerstin
Wurm, David J.
Spadiut, Oliver
Quehenberger, Julian
author_sort Rastädter, Kerstin
collection PubMed
description The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. The main biotechnological application of the membrane lipids of Sulfolobus spp. are so called archaeosomes. Archaeosomes are liposomes which are fully or partly generated from archaeal lipids and harbor the potential to be used as drug delivery systems for vaccines, proteins, peptides and nucleic acids. This review summarizes the influence of environmental parameters on the cell membrane of Sulfolobus spp. and the biotechnological applications of their membrane lipids.
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spelling pubmed-73125802020-06-29 The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications Rastädter, Kerstin Wurm, David J. Spadiut, Oliver Quehenberger, Julian Int J Mol Sci Review The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. The main biotechnological application of the membrane lipids of Sulfolobus spp. are so called archaeosomes. Archaeosomes are liposomes which are fully or partly generated from archaeal lipids and harbor the potential to be used as drug delivery systems for vaccines, proteins, peptides and nucleic acids. This review summarizes the influence of environmental parameters on the cell membrane of Sulfolobus spp. and the biotechnological applications of their membrane lipids. MDPI 2020-05-30 /pmc/articles/PMC7312580/ /pubmed/32486295 http://dx.doi.org/10.3390/ijms21113935 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rastädter, Kerstin
Wurm, David J.
Spadiut, Oliver
Quehenberger, Julian
The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
title The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
title_full The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
title_fullStr The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
title_full_unstemmed The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
title_short The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications
title_sort cell membrane of sulfolobus spp.—homeoviscous adaption and biotechnological applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312580/
https://www.ncbi.nlm.nih.gov/pubmed/32486295
http://dx.doi.org/10.3390/ijms21113935
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