SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by neuropathological hallmarks consisting of accumulation of extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles (NFT). Recently, we have identified a new AD therapeutic candidate, ethyl-8′-m...

Descripción completa

Detalles Bibliográficos
Autores principales: Izumi, Hisanao, Kawahata, Ichiro, Shinoda, Yasuharu, Helmstetter, Fred J., Fukunaga, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312612/
https://www.ncbi.nlm.nih.gov/pubmed/32481611
http://dx.doi.org/10.3390/ijms21113833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312612/
https://www.ncbi.nlm.nih.gov/pubmed/32481611
http://dx.doi.org/10.3390/ijms21113833

Ejemplares similares